Microprocessor system for the analysis of physiologic and financial datasets

• US 8,152,732 B2
• Filed: 06/19/2006
• Issued: 04/10/2012
• Est. Priority Date: 08/19/1992
• Status: Active Grant

• Current Assignee: Eric N Lynn, Lawrence A. Lynn
• Original Assignee: Eric N Lynn, Lawrence A. Lynn
• Inventors: Lynn, Lawrence A., Lynn, Eric N.
• Primary Examiner(s): MALLARI, PATRICIA C
• Application Number:
  US11/455,488
• Publication Number:
  US 20070149860A1
• Time in Patent Office: 2,122 Days
• Field of Search: 600/300, 600/538, 600/534, 600/545
• US Class Current: 600/529
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/743 Displaying an image simultaneously with additional graphical information, e.g. symbols, charts, function plots
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

A system and method for organization and analysis of complex and dynamically interactive time series is disclosed. One example comprises a processor based system for relational analysis of physiologic signals for providing early recognition of catastrophic and pathologic events such as pathophysiologic divergence. The processor is programmed to identify pathophysiologic divergence of at least one of first and second physiologic parameters in relationship to the other and to output an indication of the divergence. An object-based method of iterative relational processing waveform fragments in the time domain is described wherein each more complex waveform object inherits the characteristics of the waveform objects from which it is derived. The first physiologic parameter can be the amplitude and frequency of the variation in chest wall impedance or nasal pressure and the second parameter can be a measure or indication of the arterial oxygen saturation.

Claims

1. A method for titration of airway pressure in the treatment of sleep disordered breathing, comprising:

a processor searching a plurality of multi-signal objects, wherein the plurality of multi-signal objects includes data from at least two signals, wherein the at least two signals includes signals from at least one of oximetry, chest wall movement, or EEG data, the multi-signal objects indicating a pattern of a plurality of apneas, a pattern of a plurality of hypopneas, or a pattern of a combination of at least one apnea and at least one hypopnea; and

an auto-titration continuous positive airway pressure system titrating a pressure to a nasal passage of a patient if the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea is detected.

2. The method recited in claim 1, wherein the pattern of the plurality of apneas comprises a plurality of desaturation events.

3. The method recited in claim 2, wherein each of the plurality of desaturation events comprises at least a 4% substantially uninterrupted decrement in saturation below a defined baseline mean of oxygen saturation.

4. The method recited in claim 1, wherein the pattern of the plurality of apneas comprises a plurality of resaturation events.

5. The method recited in claim 4, wherein a resaturation event comprises a substantially uninterrupted rise in saturation which terminates a declining slope of a corresponding desaturation event.

6. The method recited in claim 1, comprising titrating the at least one pressure until the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea ceases.

7. The method recited in claim 1, wherein the pattern of the plurality of apneas comprises at least one cluster of desaturation events.

8. A system for titration of airway pressure in the treatment of sleep disordered breathing, comprising:

a processor that is adapted to a plurality of multi-signal objects, wherein the plurality multi-signal objects includes data from at least two signals, wherein the at least two signals includes signals from at least one of oximetry, chest wall movement, or EEG data, the multi-signal objects indicating a pattern of a plurality of apneas, a pattern of a plurality of hypopneas, or a pattern of a combination of at least one apnea and at least one hypopnea; and

a titration device that is adapted to titrate an at least one pressure to a nasal passage of a patient in response to a signal from the processor indicating that the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea is detected.

9. The system recited in claim 8, wherein the pattern of the plurality of apneas comprises a plurality of desaturation events.

10. The system recited in claim 9, wherein each of the plurality of desaturation events comprises at least a 4% substantially uninterrupted decrement in saturation below a defined baseline mean of oxygen saturation.

11. The system recited in claim 8, wherein the pattern of the plurality of apneas comprises a plurality of resaturation events.

12. The system recited in claim 11, wherein a resaturation event comprises a substantially uninterrupted rise in saturation which terminates a declining slope of a corresponding desaturation event.

13. The system recited in claim 8, wherein the titration device is adapted to titrate the at least one pressure until the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea ceases.

14. The system recited in claim 8, wherein the pattern of the plurality of apneas comprises a plurality of clusters of desaturation events.

15. A method for titration of airway pressure in the treatment of sleep disordered breathing, comprising:

applying at least one pressure to a nasal passage of a patient;

searching a plurality of multi-signal objects, wherein the plurality of multi-signal objects includes data from at least two signals, wherein the at least two signals includes signals from at least one of oximetry, chest wall movement, or EEG data, the multi-signal objects indicating a pattern of a plurality of apneas, a pattern of a plurality of hypopneas, or a pattern of a combination of at least one apnea and at least one hypopnea;

recording an output if the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea is detected;

searching the output to identify a corresponding response of the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea to the at least one pressure; and

titrating the at least one pressure to control the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea if the corresponding response is identified.

16. The method recited in claim 15, wherein the pattern of the plurality of apneas comprises a plurality of desaturation events.

17. The method recited in claim 16, wherein each of the plurality of desaturation events comprises at least a 4% substantially uninterrupted decrement in saturation below a defined baseline mean of oxygen saturation.

18. The method recited in claim 15, wherein the pattern of the plurality of apneas comprises a plurality of resaturation events.

19. The method recited in claim 18, wherein a resaturation event comprises a substantially uninterrupted rise in saturation which terminates a declining slope of a corresponding desaturation event.

20. The method recited in claim 15, comprising titrating the at least one pressure until the pattern of the plurality of apneas, the pattern of the plurality of hypopneas, or the pattern of the combination of at least one apnea and at least one hypopnea ceases.

21. The method recited in claim 15, wherein the pattern of the plurality of apneas comprises at least one cluster of desaturation events.