Polymorphic forms α, β and γ of rifaximin
DC CAFC
First Claim
Patent Images
1. Rifaximin in polymorphic Form α
- , wherein the rifaximin Form α
has x-ray powder diffraction pattern peaks at about 7.4°
;
19.7°
;
21.0° and
22.1°
2-θ and
wherein the rifaximin has a water content of between 3.0%-4.5%.
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Abstract
Crystalline polymorphous forms of rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ, useful in the production of medicinal preparations containing rifaximin for oral and topical use and obtained by means of a crystallization carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by addition of water at a determinate temperature and for a determinate period of time, followed by a drying carried out under controlled conditions until reaching a settled water content in the end product, are the object of the invention.
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Citations
8 Claims
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1. Rifaximin in polymorphic Form α
- , wherein the rifaximin Form α
has x-ray powder diffraction pattern peaks at about 7.4°
;
19.7°
;
21.0° and
22.1°
2-θ and
wherein the rifaximin has a water content of between 3.0%-4.5%. - View Dependent Claims (2, 3, 5, 7, 8)
- , wherein the rifaximin Form α
-
4. Rifaximin in polymorphic Form β
- , wherein the rifaximin Form β
has x-ray powder diffraction pattern peaks at about 5.4°
;
9.0°
; and
20.9°
2-θ and
wherein the rifaximin has a water content of between 4.5%-5.0%.
- , wherein the rifaximin Form β
-
6. Rifaximin in polymorphic Form γ
- , wherein the rifaximin Form γ
has x-ray powder diffraction pattern peaks at about 5.0°
, 7.1°
, and 8.4°
2-θ and
wherein the rifaximin has a water content of from between 0% to 1%.
- , wherein the rifaximin Form γ
Specification
-
- Resources
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Litigation Data
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Current AssigneeAlfasigma S.p.A.
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Original AssigneeALFA Wassermann BV (Alfasigma S.p.A.)
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InventorsViscomi, Giuseppe Claudio, Campana, Manuela, Braga, Dario, Confortini, Donatella, Cannata, Vincenzo, Righi, Paolo, Rosini, Goffredo
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Primary Examiner(s)Kifle, Bruck
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Application NumberUS13/041,332Publication NumberTime in Patent Office410 DaysField of Search540/456US Class Current540/456CPC Class CodesC07B 2200/13 Crystalline forms, e.g. pol...C07D 491/22 in which the condensed syst...C07D 498/22 in which the condensed syst...
