Tissue hydration estimation by spectral absorption bandwidth measurement

• US 8,180,419 B2
• Filed: 09/27/2006
• Issued: 05/15/2012
• Est. Priority Date: 09/27/2006
• Status: Expired due to Fees

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Nellcor Puritan Bennett LLC (Medtronic Plc)
• Inventors: Debreczeny, Martin P., Baker, Clark R. Jr.
• Primary Examiner(s): Winakur, Eric
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US11/528,154
• Publication Number:
  US 20080076983A1
• Time in Patent Office: 2,057 Days
• Field of Search: 600/309, 600/310, 600/316, 600/322, 600/340, 600/473, 600/476, 356/301, 356/302
• US Class Current: 600/310
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/4869 Determining body composition
• CPC Class Codes: G01N 21/3554 for determining moisture content
• CPC Class Codes: G01N 21/3563 for analysing solids; Preparation of samples therefor
• CPC Class Codes: G01N 21/359 using near infrared light

Abstract

A system and method are provided for determining tissue hydration. Specifically, in accordance with one aspect of the present invention there is provided a method for determining tissue hydration. The method includes detecting electromagnetic radiation scattered and reflected from the living tissue and using the detected electromagnetic radiation to determine spectral absorption bandwidth. The method also includes correlating the spectral absorption bandwidth to a tissue hydration index.

Claims

1. A method for determining tissue hydration comprising:

detecting electromagnetic radiation scattered and reflected from living tissue;

using the detected electromagnetic radiation to determine a spectral absorption bandwidth by measuring a width of an absorption band substantially centered about an absorption peak; and

correlating the spectral absorption bandwidth to a tissue hydration index.

2. The method of claim 1, comprising determining peak shift and correlating peak shift and the spectral absorption bandwidth to the tissue hydration index.

3. The method of claim 1, comprising emitting electromagnetic radiation, wherein the emitting comprises using light emitting diodes (LEDs) operating in the near-infrared spectrum having a spectral bandwidth of less than approximately 75 nm.

4. The method of claim 3, comprising using LEDs having emission peaks at 1500 nm and 1450 nm.

5. The method of claim 4, comprising using an additional LED having an emission peak at 1400 nm, the method comprising combining measurements at the three wavelengths to provide an estimate of a lean water fraction in the tissue.

6. The method of claim 5, comprising:

linearly combining the logarithm of the measurements at the three wavelengths to produce a quantity related to the ratio of water-to-protein, (r), in the tissue; and

correlating the ratio to the lean water fraction, (f¹_w), by;

f¹_w=r/(1+r).

7. The method of claim 3, comprising using LEDs having emission peaks at 1550 nm, 1450 nm and 1400 nm.

8. The method of claim 3, comprising using LEDs having emission peaks at 1550 nm, 1430 nm and 850 nm.

9. The method of claim 3, comprising using LEDs having emission peaks at 1500 nm, 1450 nm, 1100 nm, and 1070 nm.

10. The method of claim 1, comprising emitting electromagnetic radiation, wherein the emitting comprises using at least one tunable laser.

11. The method of claim 1, comprising emitting electromagnetic radiation, wherein the emitting comprises using vertical-cavity surface-emitting lasers.

12. The method of claim 1, comprising emitting electromagnetic radiation, wherein the emitting comprises using a broadband source coupled with narrowband optical filters.

13. The method of claim 1, comprising emitting electromagnetic radiation, wherein the emitting comprises implementing NIR spectroscopy.

14. The method of claim 13, comprising using scanning-grating spectroscopy.

15. The method of claim 13, comprising using diode array spectroscopy.

16. The method of claim 1, wherein using the detected electromagnetic radiation to determine spectral absorption bandwidth comprises measuring absorption bandwidth separately on a short wavelength side and a long wavelength side of the absorption peak.

17. The method of claim 1, correlating the spectral absorption bandwidth to the tissue hydration index comprises calibrating the correlation based on a patient specific parameter.

18. The method of claim 1, wherein detecting electromagnetic radiation comprises using an InGaAs detector.

19. The method of claim 3, comprising using at least two LEDs having emission peaks spaced 25 to 250 nm apart in the 1800 to 2100 nm region of the spectrum.

20. The method of claim 1, wherein the absorption band comprises a water absorption band, and the spectral absorption bandwidth comprises the width between a short wavelength side and a long wavelength side of the absorption peak at approximately half intensity of a maximum intensity of the absorption peak.

21. A system for measurement of living tissue comprising:

a sensor unit configured to emit and detect electromagnetic radiation; and

a hydration index unit coupled to the sensor unit and configured to determine a spectral absorption bandwidth by measuring a width of an absorption band substantially centered about an absorption peak and to correlate the spectral absorption bandwidth to living tissue hydration.

22. The system of claim 21, comprising a display configured to output a tissue hydration estimation.

23. The system of claim 21, wherein the sensor unit comprises at least one emitter and at least one detector.

24. The system of claim 23, wherein the at least one emitter operates in the 1300 nm to 1650 nm spectral region.

25. The system of claim 23, wherein the at least one emitter comprises a first LED operating at 1500 nm having a spectral bandwidth of less than 75 nm and a second LED operating at 1450 nm having a spectral bandwidth of less than 75 nm.

26. The system of claim 25, wherein the at least one emitter comprises a third LED operating at 1400 nm having a spectral bandwidth of 75 nm or less.

27. The system of claim 23, wherein the at least one detector comprises an InGaAs photodetector.

28. The system of claim 21, wherein the hydration index unit is configured to determine peak shift and correlate peak shift and spectral absorption bandwidth to hydration.

29. The system of claim 21, wherein the hydration index unit and the sensor unit are integrated into the same housing.

30. The system of claim 21, wherein the sensor unit comprises a tunable laser.

31. The system of claim 21, wherein the sensor comprises a broadband source coupled with narrowband optical filters.

32. The system of claim 21, wherein the sensor comprises a vertical-cavity surface-emitting laser.

33. The system of claim 21, wherein the sensor comprises a scanning-grating spectroscope.

34. The system of claim 21, wherein the sensor comprises a diode array spectroscope.

35. The system of claim 21, wherein the hydration index unit is configured to determine spectral absorption bandwidth by measuring absorption bandwidth separately on a short wavelength side and a long wavelength side of an absorption peak.

36. The system of claim 21, wherein the hydration index unit is configured to correlating the spectral absorption bandwidth to living tissue hydration by calibrating the correlation based on a patient specific parameter.

37. The system of claim 21, wherein the absorption band comprises a water absorption band, and the spectral absorption bandwidth comprises the width between a short wavelength side and a long wavelength side of the absorption peak at approximately half intensity of a maximum intensity of the absorption peak.