Method and apparatus for the treatment of movement disorders
First Claim
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1. A system for treating a neurological movement disorder, the system comprising:
- an implantable medical device comprising a housing for a power supply, memory, and electronic circuitry; and
at least one electrode in communication with the device and adapted to acquire a physiological signal from a brain of a patient, the device being adapted to;
acquire the physiological signal from the brain of the patient;
measure a first value from the physiological signal, the first value representative of an amount of oscillatory activity in a first frequency range;
measure a second value from the physiological signal, the second value representative of an amount of oscillatory activity in a second frequency range;
calculate a biomarker from the first and second values; and
use the biomarker to assess the movement disorder, the biomarker being based on a comparison of the first and second values, and the first and second frequency ranges comprising beta and gamma frequency ranges, respectively.
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Abstract
A method, apparatus, and system for treating patients suffering from movement disorders having the ability to determine one or more biomarkers indicative of a disease state. In some embodiments, the biomarker may be used as a closed-loop feedback signal to control the delivery of therapy (such as electrical stimulation or drug therapy), and which may also be used as an indication of therapy effectiveness. One embodiment uses electrodes placed in the brain to measure EEG or local field potential (LFP) signals, from which the one or more biomarkers may be determined.
148 Citations
54 Claims
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1. A system for treating a neurological movement disorder, the system comprising:
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an implantable medical device comprising a housing for a power supply, memory, and electronic circuitry; and at least one electrode in communication with the device and adapted to acquire a physiological signal from a brain of a patient, the device being adapted to; acquire the physiological signal from the brain of the patient; measure a first value from the physiological signal, the first value representative of an amount of oscillatory activity in a first frequency range; measure a second value from the physiological signal, the second value representative of an amount of oscillatory activity in a second frequency range; calculate a biomarker from the first and second values; and use the biomarker to assess the movement disorder, the biomarker being based on a comparison of the first and second values, and the first and second frequency ranges comprising beta and gamma frequency ranges, respectively. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. An implantable medical device (IMD) for treating neurological movement disorders, the device comprising:
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one or more electrodes adapted to acquire a physiological signal from a brain of a patient; and a processing subsystem adapted to determine a first value and a second value from the physiological signal, the first value representative of an amount of oscillatory activity in a first frequency range, the second value representative of an amount of oscillatory activity in a second frequency range, the processing subsystem further adapted to calculate a biomarker as a function of the first and second values, the biomarker providing an assessment of the movement disorder. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. A method of treating a neurological movement disorder, the method comprising:
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acquiring, with a medical device, a physiological signal from a brain of a patient; measuring a first value from the physiological signal, the first value representative of an amount of oscillatory activity in a first frequency range; measuring a second value from the physiological signal, the second value representative of an amount of oscillatory activity in a second frequency range; calculating, with a processor, a biomarker as a function of the first and second values; and using the biomarker to assess the movement disorder, the biomarker being based on a comparison of the first and second values, and the first and second frequency ranges comprising beta and gamma frequency ranges, respectively. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A non-transitory computer-readable medium programmed with instructions for performing a method of treating a neurological movement disorder, the computer-readable medium comprising instructions that, when executed by a programmable processor, cause the programmable processor to:
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acquire a physiological signal from a brain of a patient; measure a first value from the physiological signal, the first value representative of an amount of oscillatory activity in a first frequency range; measure a second value from the physiological signal, the second value representative of an amount of oscillatory activity in a second frequency range; calculate a biomarker from the first and second values; and use the biomarker to assess the movement disorder, the biomarker being based on a comparison of the first and second values, and the first and second frequency ranges comprising beta and gamma frequency ranges, respectively. - View Dependent Claims (47, 48)
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49. A method of treating a neurological movement disorder, the method comprising:
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acquiring, with a medical device, a physiological signal from a brain of a patient; determining a first value and a second value from the physiological signal, the first value representative of an amount of oscillatory activity in a first frequency range, the second value representative of an amount of oscillatory activity in a second frequency range; calculating, with a processor, a biomarker as a function of the first value and the second value; and using the biomarker to assess the movement disorder. - View Dependent Claims (50, 51, 52, 53, 54)
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Specification