External continuous field tomography
First Claim
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1. A method of evaluating a tissue location in a subject, the method comprising:
- (a) generating a substantially linear field gradient in the subject across the tissue location by broadcasting from a plurality of broadcasting electrodes coupled to a signal generator a respective number of multi-frequency signals, wherein each one of the multi-frequency signals is a summation of signals with different frequencies and wherein the signals with the different frequencies in the each one of the multi-frequency signals are assigned with corresponding amplitudes to form the substantially linear field gradient;
(b) obtaining a linear field gradient dependent reading from a sensing element, wherein the sensing element is configured to physically attach to the tissue location with an attachment element such that movement of the sensing element coincides with movement of the tissue location and wherein the linear field gradient dependent reading is associated with a location of the sensing element in the substantially linear field gradient; and
(c) evaluating the tissue location based on the linear field gradient dependent reading.
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Abstract
Methods for evaluating tissue motion of a tissue location, e.g., a cardiac location, via external continuous field tomography are provided. Aspects of the methods include generating at least one substantially linear continuous field gradient across the tissue location of interest, and using a resultant signal from a sensing element stably associated with the tissue location to evaluate motion of the tissue location. Also provided are systems, devices and related compositions for practicing the subject methods. The subject methods and devices find use in a variety of different applications, including cardiac resynchronization therapy.
62 Citations
25 Claims
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1. A method of evaluating a tissue location in a subject, the method comprising:
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(a) generating a substantially linear field gradient in the subject across the tissue location by broadcasting from a plurality of broadcasting electrodes coupled to a signal generator a respective number of multi-frequency signals, wherein each one of the multi-frequency signals is a summation of signals with different frequencies and wherein the signals with the different frequencies in the each one of the multi-frequency signals are assigned with corresponding amplitudes to form the substantially linear field gradient; (b) obtaining a linear field gradient dependent reading from a sensing element, wherein the sensing element is configured to physically attach to the tissue location with an attachment element such that movement of the sensing element coincides with movement of the tissue location and wherein the linear field gradient dependent reading is associated with a location of the sensing element in the substantially linear field gradient; and (c) evaluating the tissue location based on the linear field gradient dependent reading. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A system of evaluating a tissue location in a subject, the system comprising:
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(a) a plurality of broadcasting electrodes coupled to a signal generator and configured to generate a substantially linear field gradient in the subject across the tissue location by broadcasting a respective number of multi-frequency signals, wherein each one of the multi-frequency signals is a summation of signals with different frequencies and wherein the signals with the different frequencies in the each one of the multi-frequency signals are assigned with corresponding amplitudes to form the substantially linear field gradient; (b) a sensing element configured to obtain a linear field gradient dependent reading, wherein the sensing element is configured to physically attach to the tissue location with an attachment element such that movement of the sensing element coincides with movement of the tissue location and wherein the linear field gradient dependent reading is associated with a location of the sensing element in the substantially linear field gradient; (c) a signal processing element configured to evaluate the linear field gradient dependent reading to determine the tissue location.
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Specification