Integrated glucose monitor and insulin injection pen with automatic emergency notification

• US 8,206,340 B2
• Filed: 08/18/2010
• Issued: 06/26/2012
• Est. Priority Date: 08/18/2010
• Status: Active Grant

• Current Assignee: Thuban Incorporated
• Original Assignee: Thuban Incorporated
• Inventors: Arefieg, Rana J.
• Primary Examiner(s): Desanto, Matthew F
• Application Number:
  US12/806,669
• Publication Number:
  US 20120046606A1
• Time in Patent Office: 678 Days
• Field of Search: 604 65- 67, 604131-155, 600/300, 600/347, 600/309, 600/365
• US Class Current: 604/66
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/1112 Global tracking of patients, e.g. by using GPS
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150358 Strips for collecting blood, e.g. absorbent optical reagent test strips G01N21/8483; chemical reagent test strips G01N33/4875, G01N33/52
• CPC Class Codes: A61B 5/150412 Pointed piercing elements, e.g. needles, lancets for piercing the skin blade-like piercing elements A61B5/150442
• CPC Class Codes: A61B 5/150503 Single-ended needles hollow piercing element tip design A61B5/150396, needle sets for catheters A61M25/06, needles for bringing media into the body A61M5/32
• CPC Class Codes: A61B 5/150854 long distance, e.g. between patient's home and doctor's office
• CPC Class Codes: A61B 5/15105 Purely manual piercing, i.e. the user pierces the skin without the assistance of any driving means or driving devices
• CPC Class Codes: A61B 5/15186 Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
• CPC Class Codes: A61B 5/157 Devices characterised by integrated means for measuring characteristics of blood
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/741 using synthesised speech
• CPC Class Codes: A61B 5/747 in case of emergency, i.e. alerting emergency services
• CPC Class Codes: A61B 5/749 Voice-controlled interfaces
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/3553 remote, e.g. between patient's home and doctor's office
• CPC Class Codes: A61M 2205/3576 with non implanted data transmission devices, e.g. using external transmitter or receiver
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/31546 : Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: G16H 40/67 : for remote operation

Abstract

A portable insulin injection pen and blood glucose monitoring device is integrated into a single unit for testing and treating diabetes symptoms. The device has a housing of a size suitable for transport in a user'"'"'s clothing pocket or handbag. Within the housing is a blood glucose monitoring system for receiving a sample of the user'"'"'s blood and detecting its glucose level, an insulin injection mechanism for administering an insulin injection, and a microprocessor that calculates an insulin dosage appropriate to the detected blood glucose level and sets the insulin injection mechanism to administer the calculated insulin dosage. A communication device automatically informs a remote emergency service provider, such as 911 or an emergency service to which the user has subscribed, if the microprocessor determines that the detected blood glucose level presents a potential danger to the user. The microprocessor also calculates treatment regimens specific to a particular user based on the detected blood glucose level and displays the treatment regimens on an LCD display. In a particularly advantageous embodiment, a GPS receiver within the housing detects the location of the device, and the communication device, which can be a cellular telephone separate from the housing connected wirelessly to the unit via a Bluetooth connection or cellular telephone circuitry within the housing itself, transmits information regarding the location to the remote emergency service.

Claims

1. A portable blood glucose monitoring device and insulin administering pen integrated into a single unit for testing and treating diabetes symptoms in a user, the device comprising:

a housing of a size suitable for transport in a handbag or clothing pocket of the user;

a blood glucose monitoring system in said housing for receiving a sample of the user'"'"'s blood, said blood glucose monitoring system being operable to detect the glucose level in the blood sample;

an insulin administration mechanism in said housing for administering an insulin dosage to the user;

a microprocessor in said housing for calculating an insulin dosage appropriate to a hyperglycemic detected blood glucose level, wherein said insulin administration mechanism is operable to provide a signal to said microprocessor indicating that an insulin dosage has been administered;

a display mounted on said housing for displaying the detected blood glucose level and the calculated insulin dosage;

a manually operable mode switch on said housing having a first position for actuating said blood glucose monitoring system to cause detection of the glucose level in the received blood sample and a second position for administering an insulin dosage;

a sensor for sensing when said administration mechanism is in place for administering insulin, wherein setting said mode switch to the second position automatically provides a signal to said microprocessor to cause said insulin administering mechanism to administer an insulin dosage when the sensor indicates that said administering mechanism is in place; and

a communication device in said housing and under the control of said microprocessor for automatically informing a remote emergency service provider if said microprocessor determines that the detected blood glucose level presents a potential danger to the user and if said insulin administration mechanism fails to indicate that an insulin dosage has been administered within a predetermined time interval after said microprocessor determines that the detected blood glucose level presents a potential danger.

2. A device as in claim 1, further comprising at least one manual input device operable by the user in conjunction with information displayed on said display for providing a user interface permitting the user to set an insulin dosage that is changed from the calculated insulin dosage, wherein when said mode switch is in said second position said insulin administration mechanism is operable to administer the different insulin dosage if the calculated insulin dosage has been changed and to administer the calculated insulin dosage if it has not been changed.

3. A device as in claim 2, wherein:

said device stores information regarding a particular user'"'"'s treatment requirements and said microprocessor determines treatment regimens specific to the particular user based on the detected blood glucose level and the stored information;

said treatment regimens include (i) ingestion of at least one blood glucose producing substance, if the detected blood glucose level indicates that the user is hypoglycemic, and (ii) administration of insulin, if the detected blood glucose level indicates that the user is hyperglycemic; and

said microprocessor causes said display to indicate (i) an amount of the at least one blood glucose producing substance to be consumed, if the detected blood glucose level indicates that the user is hypoglycemic, or (ii) the calculated insulin dosage, if the detected blood glucose level indicates that the user is hyperglycemic, or (iii) the different insulin dosage if the calculated insulin dosage has been changed.

4. A device as in claim 3, wherein receipt by said microprocessor of a signal from said sensor when said switch is in the second position changes said display to indicate a time interval after which the insulin dosage will be automatically administered.

5. A device as in claim 4, wherein said insulin administration mechanism includes a hypodermic needle for injecting the insulin dosage and said sensor senses when said needle has penetrated the skin of the user.

6. A device as in claim 2, wherein said microprocessor further includes dose lock software that causes said display to display a prompt requiring the user to confirm the desire to change the amount of insulin to be administered before permitting said insulin administration mechanism to administer the different insulin dosage set by the user.

7. A device as in claim 1, wherein said communication device includes a cellular telephone and the remote emergency service provider is at least one of a public emergency service provider and an emergency service to which the user has subscribed.

8. A device as in claim 7, wherein said communication device is at least one of (i) a cellular telephone separate from said housing and circuitry within said housing for establishing a wireless connection to said cellular telephone, and (ii) cellular telephone circuitry within said housing.

9. A device as in claim 1, further comprising circuitry in said housing for detecting the location of the device, wherein said communication device transmits information regarding the location to the remote emergency service provider.

10. A device as in claim 9, wherein said circuitry for detecting the location of the device comprises a GPS receiver.

11. A device as in claim 1, wherein said device stores information regarding a particular user'"'"'s treatment requirements and said microprocessor determines treatment regimens specific to the particular user based on the detected blood glucose level and the stored information and displays the treatment regimens on said display.

12. A device as in claim 11, wherein said treatment regimens include:

ingestion of at least one blood glucose producing substance in an amount determined by said microprocessor based on the detected blood glucose level, if the detected blood glucose level indicates that the user is hypoglycemic; and

administration of the calculated insulin dosage determined by said microprocessor based on the detected blood glucose level, if the detected blood glucose level indicates that the user is hyperglycemic.

13. A device as in claim 1, wherein said insulin administration mechanism includes a hypodermic needle for injecting the insulin dosage and said sensor senses when said needle has penetrated the skin of the user.

14. A device as in claim 1, wherein said mode switch has a neutral position and said microprocessor displays a prompt on said display instructing the user to take a blood sample and detect the glucose level thereof when said mode switch is moved from its neutral position to its first position.

15. A device as in claim 1, wherein receipt by said microprocessor of a signal from said sensor when said switch is in the second position causes said display to indicate a time interval after which the insulin dosage will be automatically administered.