System and method to design structure for delivering electrical energy to tissue

• US 8,209,027 B2
• Filed: 11/28/2006
• Issued: 06/26/2012
• Est. Priority Date: 07/07/2004
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Butson, Christopher R., McIntyre, Cameron
• Primary Examiner(s): Layno, Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US11/606,260
• Publication Number:
  US 20070083104A1
• Time in Patent Office: 2,037 Days
• Field of Search: 607/115, 607/2, 607/116, 600/372, 600/587, 600/439, 600/427
• US Class Current: 607/59
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation

Abstract

A computer-assisted method can include defining a target volume of tissue activation to achieve a desired therapeutic effect for an identified anatomic region. At least one parameter can be computed for an electrode design as a function of the defined target volume of tissue activation. The computed at least one parameter can be stored in memory for the electrode design, which parameter can be utilized to construct an electrode.

Claims

1. A method for determining an electrode design, comprising:

selecting an anatomical region to achieve a desired therapeutic effect;

defining a target volume of tissue activation in the selected anatomical region expected to achieve the desired therapeutic effect;

determining at least one electrode structure parameter and at least one stimulation parameter that provides a design volume of tissue activation that substantially matches the target volume of tissue activation;

storing the determined at least one electrode structure parameter and the at least one stimulation parameter to define the electrode design.

2. The method of claim 1, wherein the at least one electrode structure parameter comprises dimensions for at least one contact of the electrode design.

3. The method of claim 2, wherein the dimensions for the at least one contact further comprise a dimension along a longitudinal axis and a cross-sectional dimension.

4. The method of claim 1, wherein a parameter search space is provided that includes a plurality of electrode structure parameters and a plurality of stimulation parameters, the determination further comprising:

searching through the parameter search space to ascertain which combination of the plurality of electrode structure parameters and a plurality of stimulation parameters produces an electrode design expected to substantially match the target volume of tissue activation.

5. The method of claim 4 further comprising:

selecting a subset of plural electrode designs expected to substantially match the target volume of tissue activation;

characterizing changes in the design volume of tissue activation for each electrode design in the selected subset according to changes in at least one of contact location parameter and electrode trajectory parameter; and

identifying which electrode design in the selected subset exhibits increased resilience, relative to other electrode designs, to the changes in at least one of contact location parameter and electrode trajectory parameter.

6. The method of claim 1 wherein the at least one structural parameter comprises an aspect ratio defined by a ratio of a diameter and a length of the contact dimensions.

7. The method of claim 1, wherein the electrode design comprises a plurality of contacts spaced apart from each other along a longitudinal axis, the at least one structural parameter further comprising a relative spacing between at least two of the plurality of contacts along the longitudinal axis.

8. The method of claim 1, further comprising generating a score for the design volume of tissue activation to characterize an amount of overlap between the design volume of tissue activation and the target volume of tissue activation.

9. The method of claim 8, wherein the scoring further comprising applying a penalty to the score according to a spread of the design volume of tissue activation that extends outside the boundary of the target volume of tissue activation.

10. The method of claim 1, wherein the determination of the design volume tissue activation further comprises predicting effects of neural stimulation, according to the at least one electrode structure parameter and at least one stimulation parameter, for the anatomical region based on at least one threshold that characterizes an activation potential for the anatomical region in response to electrical stimulation.

11. The method of claim 1, wherein the defined target volume of tissue activation comprises a probabilistic definition that represents the anatomical region expected to achieve the desired therapeutic effect.