Method of calibrating an analyte-measurement device, and associated methods, devices and systems

  • US 8,219,175 B2
  • Filed: 06/29/2009
  • Issued: 07/10/2012
  • Est. Priority Date: 10/31/2003
  • Status: Expired due to Fees
First Claim
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1. An in vivo glucose sensor calibration system, comprising:

  • at least one analyte sensor including one or more working electrodes each including a portion which is subcutaneously positioned to generate one or more signals associated with a monitored glucose level;

    a calibration sensor configured to be placed in contact with a blood sample from an off-finger calibration site to provide a calibration measurement; and

    one or more processors operatively coupled to one or more of the one or more working electrodes or the calibration sensor, the one or more processors configured to compare the generated one or more signals from the one or more working electrodes to determine if the one or more signals differ by a predetermined threshold amount, to convert the one or more signals to a glucose concentration level using the calibration measurement based on the comparison, to determine a sensitivity of the at least one analyte sensor, and to determine a temperature compensated glucose concentration by dividing at least one value of the one or more signals by the sensitivity value and multiplying by a temperature compensation factor that is raised to a power equal to the difference in the temperature at a time associated with a calibration point and the temperature at the time associated with the generated one or more signals.

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