Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity

  • US 8,222,244 B2
  • Filed: 05/17/2011
  • Issued: 07/17/2012
  • Est. Priority Date: 10/30/2001
  • Status: Active Grant
First Claim
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1. A method for treating a mammal suffering from acute myeloid leukemia comprising administering to a mammal in need of such treatment a therapeutically effective amount of N-[(9S,10R,11R,13R)-2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:

  • 3′

    ,2′

    ,1′

    -Im]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl]-N-methylbenzamide of the formula (VII);

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