Analyte monitoring device and methods of use

  • US 8,224,413 B2
  • Filed: 10/10/2008
  • Issued: 07/17/2012
  • Est. Priority Date: 04/30/1998
  • Status: Expired due to Fees
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First Claim
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1. A method of making a biosensor, comprising:

  • providing a flexible insulative substrate;

    providing a conductive material;

    forming an electrode of the conductive material on the substrate using photolithography; and

    providing an analyte responsive enzyme to the substrate, at least a portion of the substrate with the analyte responsive enzyme positionable under a skin layer of a user;

    wherein the flexibility of the biosensor is controlled and varied along a continuum based on the composition and the thickness of the substrate, the thickness of the substrate determined by the strength and the modulus of the substrate material, and further, wherein the flexibility of the biosensor provides the biosensor to be bent when the at least the portion of the substrate with the analyte responsive enzyme is positioned under the skin layer of the user.

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