Transdermal estrogen device and delivery

  • US 8,231,906 B2
  • Filed: 07/10/2008
  • Issued: 07/31/2012
  • Est. Priority Date: 07/10/2008
  • Status: Active Grant
First Claim
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1. A monolithic transdermal drug delivery system for estradiol, comprising a single polymer matrix layer defining an active surface area and comprising a polymer matrix comprising estradiol as the only drug, wherein the polymer matrix layer has a coat weight selected from the group consisting of 12.5 mg/cm2 and 15 mg/cm2, includes greater than 0.156 mg/cm2 estradiol, and achieves an estradiol flux that is greater than 0.01 mg/cm2/day, based on the active surface area.

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