Compositions and methods for enhancing corticosteroid delivery

  • US 8,232,264 B2
  • Filed: 01/29/2009
  • Issued: 07/31/2012
  • Est. Priority Date: 12/21/2001
  • Status: Active Grant
First Claim
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1. A composition consisting essentially ofOne or more corticosteroids;

  • Two or more penetration enhancers selected from the group consisting of diisopropyl adipate, dimethyl isosorbide, propylene glycol, 1,2,6-hexanetriol, and benzyl alcohol; and

    One or more of the group consisting of solvents and emulsifiers, wherein the solvents and emulsifiers are selected from the group consisting of dehydrated alcohol, alcohol (95% v/v) USP, 3-Cyclohexene-1-Methanol, .α

    .4-Dimethyl-a-(4-Methyl-3-Pentenyl)-, Steareth-2, Steareth-21, citric acid, CPE-215, diisopropanolamine (1;

    9), DIPA/PG (1;

    9), ethoxydiglycol, Potassium hydroxide (10%), PEG40 Stearate, PEG-7000, Polysorbate 60, potassium hydroxide (1%), propylene carbonate USP, propylethylene glycol4, oleyl alcohol, sodium lauryl sulfate, sorbitan monostearate, sorbitan stearate, and 1,2,3-Propanetriol Ester, and wherein the penetration enhancers are present in a ratio to a total of the penetration enhancers, and solvents and emulsifiers of at least about 0.9.

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