Inhaler

• US 8,245,705 B2
• Filed: 02/19/2007
• Issued: 08/21/2012
• Est. Priority Date: 02/21/2006
• Status: Active Grant

• Current Assignee: Jianhe Li
• Original Assignee: Jianhe Li
• Inventors: Li, Jianhe
• Primary Examiner(s): Thanh, Loan
• Assistant Examiner(s): Philips, Bradley
• Application Number:
  US12/280,222
• Publication Number:
  US 20090064997A1
• Time in Patent Office: 2,010 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.23, 128/203.24, 128/203.25, 128/200.14, 128/200.23, 128/200.24
• US Class Current: 128/200.23
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0068 Indicating or counting the number of dispensed doses or of remaining doses
• CPC Class Codes: A61M 15/0086 Inhalation chambers
• CPC Class Codes: A61M 15/0091 mechanically breath-triggered
• CPC Class Codes: A61M 15/0096 Hindering inhalation before activation of the dispenser
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/0233 Conductive materials, e.g. antistatic coatings for spark prevention
• CPC Class Codes: A61M 2205/073 Syringe, piston type
• CPC Class Codes: A61M 2205/8225 using incorporated gas cartridges for the driving gas
• CPC Class Codes: A61M 2206/14 Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
• CPC Class Codes: A61M 2206/16 Rotating swirling helical flow, e.g. by tangential inflows

Abstract

The invention provides an inhaler for dispensing medicament. The inhaler comprises auxiliary energy provision means for providing auxiliary energy for aerosolizing medicament; energy release means for releasing auxiliary energy from the auxiliary energy provision means; feed means for feeding a dose of medicament, characterized in that the inhaler comprises control means for controlling a time interval between aerosolization of the medicament and a user'"'"'s inhalation. The inhaler is operable, in use, to aerosolize medicament using the auxiliary energy, and harness the user'"'"'s inhalation to deliver the aerosolized medicament to the user.

Claims

1. An inhaler for dispensing medicament, the inhaler comprising:

a gas container for containing compressed gas, the compressed gas being releasable from the gas container to aerosolise said medicament; and

control means comprising a valve for controlling the passage of fresh air from the outside atmosphere to the user via a conduit;

said control means being configured to control a time interval between the aerosolisation of the medicament and the opening of the valve to allow the user'"'"'s inhalation of fresh air from the outside atmosphere in response to a change in the volume and/or pressure of the gas in the gas container;

wherein the inhaler is operable, in use, to aerosolise the medicament using the compressed gas, and harness the user'"'"'s inhalation of fresh air from the outside atmosphere to deliver the aerosolised medicament to the user by opening the valve after the time interval controlled by the control means; and

wherein said compressed gas in said gas container can be released by means comprising;

a valve used to control an air channel, and

a trigger, which can be actuated manually and/or by the user'"'"'s suction force.

2. An inhaler for dispensing medicament, the inhaler comprising:

a gas container for containing compressed gas, the compressed gas being releasable from the gas container to aerosolise said medicament; and

control means comprising a valve for controlling the passage of fresh air from the outside atmosphere to the user via a conduit;

a drug feeder that is actuated upon charging of said gas container;

said control means being configured to control a time interval between the aerosolisation of the medicament and the opening of the valve to allow the user'"'"'s inhalation of fresh air from the outside atmosphere in response to a change in the volume and/or pressure of the gas in the gas container;

wherein the inhaler is operable, in use, to aerosolise the medicament using the compressed gas, and harness the user'"'"'s inhalation of fresh air from the outside atmosphere to deliver the aerosolised medicament to the user by opening the valve after the time interval controlled by the control means; and

wherein said drug feeder comprises a device that is used to measure a unit dose of drug powder from a powder reservoir.

3. A dry powder inhaler for dispensing medicament, the dry powder inhaler comprising:

a gas container for containing compressed gas, the compressed gas being releasable from the gas container to aerosolise said medicament; and

control means comprising a valve for controlling the passage of fresh air from the outside atmosphere to the user via a conduit;

said control means being configured to control a time interval between the aerosolisation of the medicament and the opening of the valve to allow the user'"'"'s inhalation of fresh air from the outside atmosphere in response to a change in the volume and/or pressure of the gas in the gas container;

wherein the dry powder inhaler is operable, in use, to aerosolise the medicament using the compressed gas, and harness the user'"'"'s inhalation of fresh air from the outside atmosphere to deliver the aerosolised medicament to the user by opening the valve after the time interval controlled by the control means.

4. The inhaler according to claim 3, wherein the volume of the gas container is adapted to vary in response to a change in the pressure of the gas contained therein.

5. The inhaler according to claim 3, wherein the gas container comprises a piston slideably mounted therein, which piston is moveable between a first, “

rest position”

in which the volume of the container is at a first value when the pressure of gas in the container is at a first value, and a second, “

engaged position”

, in which the volume of the container is at a second higher value when the pressure of gas in the container is at a second higher value.

6. The inhaler according to claim 3, wherein the piston is biased towards the first position.

7. The inhaler according to claim 3, further comprising;

a spiral gas conduit used to make spiral flow of said gas and/or air so as to entrain and to disperse said medicament effectively;

or

a cylinder cavity, where said medicament is, said gas and/or air being introduced via a gas channel at an optimised angle and exiting said cavity in a perpendicular direction so as to produce cyclone flow of said gas and/or air and hence to entrain and to disperse said medicament.

8. The inhaler according to claim 3, wherein the change in the volume and/or pressure of the gas in the gas container is detected by a sensor selected from a group comprising:

a piston that directly detects and responds to the changes in volume and/or pressure of said gas container; and

a pressure gauge that can detect the change in pressure of said gas container.

9. The inhaler according to claim 3, wherein the control means is operable to control a time interval between the aerosolisation of the medicament and the user'"'"'s inhalation, wherein the user'"'"'s inhalation of fresh air only gets through into the user'"'"'s mouth after aerosolisation has occurred for a certain time period.

10. The inhaler according to claim 3, wherein the control means comprises a timer.

11. The inhaler according to claim 10, wherein said timer is an inherent timer which is the combination effect of:

said gas container,

a sensor or sensors,

said valve, and

a trigger which can be selected from a group comprising of;

a cylinder with a piston having a attached rod;

a cylinder with a diaphragm having a attached rod;

other methods working as a trigger to open said valve;

whereby said sensor or sensors detect changes in said gas container, actuates said trigger to open said valve after a time interval so as to allow the fresh air going through the air channel for the user to inhale when said inhaler is in action.

12. A method of administering a dose of medicament to a subject, the method comprising the use of an inhaler according to claim 3.