Microneedle transdermal transport device

• US 8,246,582 B2
• Filed: 04/29/2008
• Issued: 08/21/2012
• Est. Priority Date: 10/26/2001
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Angel, Aimee B., Hunter, Ian W.
• Primary Examiner(s): KOHARSKI, CHRISTOPHER
• Application Number:
  US12/150,606
• Publication Number:
  US 20080281273A1
• Time in Patent Office: 1,575 Days
• Field of Search: 604/22, 604/890.1, 604/65, 604/66, 604/67, 604/131, 604/132, 604/151, 604/173
• US Class Current: 604/173
• CPC Class Codes: A61M 2005/1405 Patient controlled analgesia [PCA]
• CPC Class Codes: A61M 2005/14204 with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14252 with needle insertion means
• CPC Class Codes: A61M 2005/14268 with a reusable and a disposable component
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/003 having a lumen
• CPC Class Codes: A61M 2037/0038 having a channel at the side surface
• CPC Class Codes: A61M 2205/0266 Shape memory materials
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2230/65 Impedance, e.g. conductivity, capacity
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/155 pressurised by gas introduced into the reservoir
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61M 5/425 Protruding skin to facilitate piercing, e.g. vacuum cylinders, vein immobilising means
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion

Abstract

A transdermal transport device includes a reservoir for holding a formulation of an active principle, and a needle with a bore extending along the length of the needle from a first end of the needle to a second end of the needle. The second end is substantially aligned to a plane parallel to a body surface of a biological body when the device is placed on the body surface. The device also includes an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.

Claims

1. A transdermal transport device comprising:

a reservoir for holding a formulation of an active principle;

a plurality of needles, each needle having a bore extending along a length of the needle, each needle having an end portion being substantially aligned to a common plane parallel to a body surface of a biological body when the device is placed on the body surface and being adapted to translate in a direction that is substantially parallel to the plane to pierce the body surface, the plurality of needles independently and removably securing the device to the body surface; and

an actuator which pumps the formulation through the bore of the needle between a target area of the body and the reservoir.

2. The transdermal transport device of claim 1 wherein the end portion moves in the plane parallel to the body surface of the biological body to pierce the body surface.

3. The transdermal transport device of claim 1 wherein a desired amount of formulation is dispensed from the reservoir over a particular time period.

4. The transdermal transport device of claim 3 wherein the time period is between 1 second and 10 days.

5. The transdermal transport device of claim 3 wherein the desired amount is dispensed incrementally over time.

6. The transdermal transport device of claim 3 wherein the desired amount of formulation is a sample collected from a patient drawn into the reservoir over a particular time period.

7. The transdermal transport device of claim 1 wherein the reservoir is initially empty and is filled with biological material withdrawn from the biological body.

8. The transdermal transport device of claim 7 further including a sensor arranged to monitor a concentration of a substance in the biological material withdrawn from the biological body.

9. The transdermal transport device of claim 8 wherein the substance is glucose.

10. The transdermal transport device of claim 1 wherein at least one needle includes a beveled tip.

11. The transdermal transport device of claim 1 wherein at least one needle includes holes along sidewalls along the length of the needle.

12. The transdermal transport device of claim 1 wherein the reservoir is coated with a material that aids flow of the formulation through the reservoir.