Catheters with tracking elements and permeable membranes

• US 8,246,602 B2
• Filed: 06/22/2004
• Issued: 08/21/2012
• Est. Priority Date: 12/23/2002
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Heruth, Kenneth T., Lent, Mark S., Blanco, Justin A.
• Primary Examiner(s): VU, QUYNH-NHU HOANG
• Application Number:
  US10/873,764
• Publication Number:
  US 20050137577A1
• Time in Patent Office: 2,982 Days
• Field of Search: 604/523, 604/890.1, 604/891.1, 604/93.01, 604/20, 604 65- 67, 604/500, 604/174, 604/175, 604/48, 604/264
• US Class Current: 604/523
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0166 Sensors, electrodes or the like for guiding the catheter to a target zone, e.g. image guided or magnetically guided
• CPC Class Codes: A61M 25/003 characterized by features relating to least one lumen located at the distal part of the catheter, e.g. filters, plugs or valves catheter tips A61M25/0067
• CPC Class Codes: A61M 25/0043 characterised by structural features
• CPC Class Codes: A61M 25/0105 Steering means as part of the catheter or advancing means; Markers for positioning systems for detection of markers A61B

Abstract

Devices, systems and methods for delivering one or more drugs to one or more internal body locations (such as the cerebrospinal fluid) are disclosed. In various aspects, the systems and methods may involve catheters having infusion sections with permeable membranes and one or more tracking elements that may be used to place the infusions sections on the catheters in selected locations such as the spinal region.

Claims

1. A drug delivery catheter comprising:

an elongated body comprising a proximal end and distal end;

a lumen extending along the elongated body to a first infusion section spaced from the proximal end of the elongated body;

one or more openings in the lumen within the first infusion section;

a permeable membrane covering the one or more openings in the first infusion section;

a first tracking element attached to the elongated body at a first selected location proximate the first infusion section to allow a practitioner to determine the position of the first infusion section, wherein the first tracking element comprises an active tracking element comprising a transmitter; and

a second tracking element, wherein the second tracking element is attached to the elongated body at a second selected location, and wherein the second tracking element operates on a different modality than the first tracking element.

2. The catheter of claim 1, wherein the second location is proximate the first infusion section.

3. The catheter of claim 1, wherein the first infusion section comprises an axial length of 20 mm or more.

4. The catheter of claim 1, wherein the first infusion section comprises an axial length of 320 mm or less.

5. The catheter of claim 1, further comprising a second infusion section on the elongated body.

6. The catheter of claim 5, wherein the second selected location is proximate the second infusion section.

7. The catheter of claim 5, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of 20 mm or more.

8. The catheter of claim 5, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of one human vertebral level or more.

9. The catheter of claim 1, further comprising a guidewire lumen extending from the proximal end of the elongated body to the distal end of the elongated body.

10. The catheter of claim 9, further comprising a guidewire located within the guidewire lumen.

11. The catheter of claim 10, wherein the guidewire comprises a steerable guidewire.

12. The catheter of claim 10, wherein the guidewire comprises a guidewire tracking element proximate a distal end of the guidewire.

13. A drug delivery system comprising:

a drug delivery apparatus comprising a pump and a drug reservoir;

a catheter comprising;

an elongated body comprising a proximal end and distal end;

a lumen extending along the elongated body to a first infusion section spaced from the proximal end of the elongated body;

one or more openings in the lumen within the first infusion section;

a permeable membrane covering the one or more openings in the first infusion section;

a first tracking element attached to the elongated body at a first selected location proximate the first infusion section to allow a practitioner to determine the position of the first infusion section, wherein the first tracking element comprises an active tracking element comprising a transmitter; and

a second tracking element, wherein the second tracking element is attached to the elongated body at a second selected location, and wherein the second tracking element operates on a different modality than the first tracking element; and

a tracking system adapted to determine the location of the first tracking element.

14. The system of claim 13, wherein the second location is proximate the first infusion section.

15. The system of claim 13, wherein the first infusion section comprises an axial length of 20 mm or more.

16. The system of claim 13, wherein the first infusion section comprises an axial length of 320 mm or less.

17. The system of claim 13, further comprising a second infusion section on the elongated body.

18. The system of claim 17, wherein the second selected location is proximate the second infusion section.

19. The system of claim 17, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of 20 mm or more.

20. The system of claim 17, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of one human vertebral level or more.

21. The system of claim 13, further comprising a guidewire lumen extending from the proximal end of the elongated body to the distal end of the elongated body.

22. The system of claim 21, further comprising a guidewire located within the guidewire lumen.

23. The system of claim 22, wherein the guidewire comprises a steerable guidewire.

24. The system of claim 22, wherein the guidewire comprises a guidewire tracking element proximate a distal end of the guidewire.

25. The system of claim 13, wherein the drug delivery apparatus comprises an implantable drug delivery apparatus.

26. A drug delivery catheter comprising:

an elongated body comprising a proximal end and distal end;

a lumen extending along the elongated body to a first infusion section spaced from the proximal end of the elongated body;

one or more openings in the lumen within the first infusion section;

a permeable membrane covering the one or more openings in the first infusion section;

a first tracking element attached to the elongated body at a first selected location proximate the first infusion section to allow a practitioner to determine the position of the first infusion section;

a second infusion section on the elongated body; and

a second tracking element, wherein the second tracking element is attached to the elongated body at a second selected location that is proximate the second infusion section, and wherein the second tracking element operates on a different modality than the first tracking element.

27. The catheter of claim 26, wherein the first tracking element comprises a passive tracking element.

28. The catheter of claim 26, wherein the second location is proximate the first infusion section.

29. The catheter of claim 26, wherein the first infusion section comprises an axial length of 20 mm or more.

30. The catheter of claim 26, wherein the first infusion section comprises an axial length of 320 mm or less.

31. The catheter of claim 26, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of 20 mm or more.

32. The catheter of claim 26, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of one human vertebral level or more.

33. The catheter of claim 26, further comprising a guidewire lumen extending from the proximal end of the elongated body to the distal end of the elongated body.

34. The catheter of claim 33, further comprising a guidewire located within the guidewire lumen.

35. The catheter of claim 34, wherein the guidewire comprise a steerable guide wire.

36. The catheter of claim 34, wherein the guide wire comprise a guidewire tracking element proximate a distal end of the guidewire.

37. A drug delivery system comprising:

a drug delivery apparatus comprising a pump and a drug reservoir;

a catheter comprising;

an elongated body comprising a proximal end and distal end;

a lumen extending along the elongated body to a first infusion section spaced from the proximal end of the elongated body;

one or more openings in the lumen within the first infusion section;

a permeable membrane covering the one or more openings in the first infusion section;

a first tracking element attached to the elongated body at a first selected location proximate the first infusion section to allow a practitioner to determine the position of the first infusion section,

a second infusion section on the elongated body;

a second tracking element, wherein the second tracking element is attached to the elongated body at a second selected location that is proximate the second infusion section, and wherein the second tracking element operates on a different modality than the first tracking element; and

a tracking system adapted to determine the location of the first tracking element.

38. The system of claim 37, wherein the first tracking element comprises a passive tracking element.

39. The system of claim 37, wherein the second location is proximate the first infusion section.

40. The system of claim 37, wherein the first infusion section comprises an axial length of 20 mm or more.

41. The system of claim 37, wherein the first infusion section comprises an axial length of 320 mm or less.

42. The system of claim 37, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of 20 mm or more.

43. The system of claim 37, wherein the first infusion section is spaced apart from the second infusion section along the elongated body by an axial distance of one human vertebral level or more.

44. The system of claim 37, further comprising a guidewire lumen extending from the proximal end of the elongated body to the distal end of the elongated body.

45. The system of claim 44, further comprising a guidewire located within the guidewire lumen.

46. The system of claim 45, wherein the guidewire comprises a steerable guidewire.

47. The system of claim 45, wherein the guidewire comprises a guidewire tracking element proximate a distal end of the guidewire.

48. The system of claim 37, wherein the drug delivery apparatus comprises an implantable drug delivery apparatus.