Compounds and methods for labeling oligonucleotides
First Claim
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1. A composition comprising a reporter moiety linked to an oligonucleotide through an oxime bond, wherein the reporter moiety is a compound of Formula (I):
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Abstract
A compound having the general formula shown below:
where R1-6 are independently selected from the group consisting of an electron withdrawing group, an alkyl group, an aryl group, hydrogen, a heteroaryl group, and a five or six member ring structure formed from the R1 and R2 pair, the R3 and R4 pair, the R4 and R5 pair, or the R5 and R6 pair; R7 is a substituted or unsubstituted aryl group; and Y is a nucleophile.
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11 Claims
- 1. A composition comprising a reporter moiety linked to an oligonucleotide through an oxime bond, wherein the reporter moiety is a compound of Formula (I):
Specification