Electrical muscle controller
First Claim
1. A method of treating reduced cardiac output of a beating heart, the method comprising applying an electric signal to cardiac tissue which is applied during an absolute refractory period and which is adapted to exert positive control to cardiac tissue,wherein said applying comprises applying said signal to a non-arrhythmic segment of a beating heart for at least 100 beats out of 50,000 consecutive beats.
7 Assignments
0 Petitions
Accused Products
Abstract
A method of modifying the force of contraction of at least a portion of a heart chamber, including providing a subject having a heart, comprising at least a portion having an activation, and applying a non-excitatory electric field having a given duration, at a delay after the activation, to the portion, which causes the force of contraction to be increased by a least 5%.
478 Citations
31 Claims
-
1. A method of treating reduced cardiac output of a beating heart, the method comprising applying an electric signal to cardiac tissue which is applied during an absolute refractory period and which is adapted to exert positive control to cardiac tissue,
wherein said applying comprises applying said signal to a non-arrhythmic segment of a beating heart for at least 100 beats out of 50,000 consecutive beats.
-
12. A method for modifying cardiac activity, the method comprising repeatedly applying a non-excitatory signal with a defined control sequence for a finite amount of time including a plurality of consecutive heart beats to a cardiac tissue of a beating heart, during an absolute refractory period of said tissue,
wherein said applying comprises applying said signal to a non-arrhythmic segment of a beating heart for at least 100 beats out of 50,000 consecutive beats.
-
23. A method of ameliorating a clinical severity of reduced cardiac output of a beating heart in a patient with a long term therapeutic goal of increased cardiac output, the method comprising:
-
repeatedly applying a non-excitatory electric field to at least a portion of a beating heart, the electric field characterized by a magnitude, shape, duty cycle, phase, frequency and duration suitable to obtain an increase in stroke volume, wherein said applying comprises applying said signal to a non-arrhythmic segment of a beating heart for at least 100 beats out of 50,000 consecutive beats. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30)
-
-
31. A method of cardiac modeling, the method comprising:
-
(a) applying a non-excitatory electric field to at least a portion of a heart to change a distribution of muscle mass in the heart; and (b) ceasing to apply the non excitatory electric field after a desired change in distribution of muscle mass is achieved, wherein said applying comprises applying said signal to a non-arrhythmic segment of a beating heart for at least 100 beats of a non-arrhythmically beating heart out of 50,000 consecutive beats.
-
Specification