Polymer nanofilm coatings

• US 8,263,104 B2
• Filed: 06/09/2008
• Issued: 09/11/2012
• Est. Priority Date: 06/08/2007
• Status: Expired due to Fees

• Current Assignee: Northwestern University, Regents of the University of California (University of California)
• Original Assignee: Northwestern University, Regents of the University of California (University of California)
• Inventors: Ho, Dean, Chen, Mark, Pierstorff, Erik, Huang, Houjin, Cheng, Genhong, Chow, Edward K
• Primary Examiner(s): Wax, Robert A
• Assistant Examiner(s): AL-AWADI, DANAH J
• Application Number:
  US12/135,640
• Publication Number:
  US 20090004241A1
• Time in Patent Office: 1,555 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2400/12 Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: Y10T 428/24355 Continuous and nonuniform or irregular surface on layer or component [e.g., roofing, etc.]
• CPC Class Codes: Y10T 428/24975 No layer or component greater than 5 mils thick

Abstract

Disclosed herein are nanofilm coatings for implantable medical devices comprising a diblock or triblock copolymer (PEO-PMMA or PMOXA-PDMS-PMOXA, respectively). Such nanofilms, may be used, for example, as amphiphilic supports for therapeutic agents. These materials are conducive towards the formation of active substrates for a suite of biological and medical applications.

Claims

1. An implantable medical device having one or more of its surfaces coated with a nanofilm composition comprising:

(a) a first layer comprising parylene;

(b) a second layer comprising a copolymer; and

(c) a third layer comprising nanoporous parylene,

wherein the copolymer is a triblock copolymer comprising polymethyloxazoline-polydimethylsiloxane-polymethyloxazoline, and wherein the nanofilm has a thickness between 0.1 nm and 20 nm.

2. The device of claim 1, wherein said composition further comprises at least one therapeutic agent.

3. The device of claim 2, wherein the at least one therapeutic agent is not a protein.

4. The device of claim 2, wherein the at least one therapeutic agent is selected from the group consisting of:

thrombin inhibitors, antithrombogenic agents, thrombolytic agents, fibrinolytic agents, vasospasm inhibitors, calcium channel blockers, vasodilators, antihypertensive agents, antimicrobial agents, antibiotics, inhibitors of surface glycoprotein receptors, antiplatelet agents, antimitotics, microtubule inhibitors, anti secretory agents, actin inhibitors, remodeling inhibitors, antisense nucleotides, anti metabolites, antiproliferatives, anticancer chemotherapeutic agents, anti-inflammatory steroid or non-steroidal anti-inflammatory agents, immunosuppressive agents, growth hormone antagonists, growth factors, dopamine agonists, radiotherapeutic agents, extracellular matrix components, inhibitors, free radical scavengers, chelators, antioxidants, anti polymerases, antiviral agents, photodynamic therapy agents, and gene therapy agents.

5. The device of claim 1, wherein the copolymer comprises a single layer having a thickness from about 1 nm to about 10 nm.

6. The device of claim 1, wherein the device comprises an electrode.