Polynucleotides encoding antibodies directed against amyloid-beta peptide
First Claim
Patent Images
1. A polynucleotide encoding an antibody that specifically binds an Aβ
- peptide, said polynucleotide comprising at least one nucleic acid sequence selected from the group consisting of a nucleic acid sequence encoding a heavy chain variable region comprising CDRs comprising the amino acid sequences of SEQ ID NO;
3, SEQ ID NO;
4, and SEQ ID NO;
5, and a nucleic acid sequence encoding a light chain variable region comprising CDRs comprising the amino acid sequences of SEQ ID NO;
6, SEQ ID NO;
7, and SEQ ID NO;
8.
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Abstract
Monoclonal antibody 9TL and antibodies derived from 9TL directed against amyloid-beta peptide and methods of using same for diagnosing and treatment of Alzheimer'"'"'s disease and Aβ peptide associated diseases are described. Methods of using antibodies directed against amyloid-beta peptide having impaired effector function for treatment of Alzheimer'"'"'s disease and Aβ peptide associated diseases are also described.
152 Citations
35 Claims
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1. A polynucleotide encoding an antibody that specifically binds an Aβ
- peptide, said polynucleotide comprising at least one nucleic acid sequence selected from the group consisting of a nucleic acid sequence encoding a heavy chain variable region comprising CDRs comprising the amino acid sequences of SEQ ID NO;
3, SEQ ID NO;
4, and SEQ ID NO;
5, and a nucleic acid sequence encoding a light chain variable region comprising CDRs comprising the amino acid sequences of SEQ ID NO;
6, SEQ ID NO;
7, and SEQ ID NO;
8. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
- peptide, said polynucleotide comprising at least one nucleic acid sequence selected from the group consisting of a nucleic acid sequence encoding a heavy chain variable region comprising CDRs comprising the amino acid sequences of SEQ ID NO;
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20. An isolated polynucleotide comprising the nucleic acid of the vector deposited under ATCC Accession No. PTA-6124 that encodes a heavy chain variable region of an antibody.
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21. An isolated polynucleotide comprising the nucleic acid of the vector deposited under ATCC Accession No. PTA-6125 that encodes a light chain variable region of an antibody.
- 22. An isolated polynucleotide comprising the nucleic acid sequence set forth in SEQ ID NO:
- 23. An isolated polynucleotide comprising the nucleic acid sequence set forth in SEQ ID NO:
- 33. An isolated polynucleotide encoding an antibody heavy chain polypeptide said polynucleotide comprising the nucleic acid sequence encoding the heavy chain polypeptide as comprised in vector pDb.9TL.hFc2a deposited as ATCC No. PTA-6124.
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34. An isolated polynucleotide encoding an antibody light chain polypeptide said polynucleotide comprising the nucleic acid sequence encoding the light chain as comprised in vector pEb.9TL.hK deposited as ATCC No. PTA-6125.
Specification