Method of manufacturing in vitro analyte sensors
First Claim
1. A method of manufacturing a plurality of electrochemical sensors for use in determining a concentration of an analyte in a sample of bodily fluid, the method comprising the steps of:
- (a) forming a plurality of working electrodes on a first electrode region of a substrate;
(b) forming a plurality of counter electrodes on a second electrode region of the substrate;
(c) disposing a spacer layer on one of the first and the second electrode regions;
(d) removing a portion of the spacer layer to define sample chamber regions;
(e) folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure; and
(f) separating the layered structure into a plurality of electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, and at least one sample chamber region,wherein each electrochemical sensor comprises a proximal end having a width and a distal end having a width, the distal end being configured for insertion into a sensor reader, wherein the width of the distal end is greater than the width of the proximal end.
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Accused Products
Abstract
Provided are methods of manufacturing a plurality of electrochemical sensors. The methods include forming a plurality of working electrodes on a first electrode region of a substrate, forming a plurality of counter electrodes on a second electrode region of the substrate, disposing a spacer layer on one of the first and second electrode regions, folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure, and separating or cutting the layered structure to form individual electrochemical sensors.
464 Citations
28 Claims
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1. A method of manufacturing a plurality of electrochemical sensors for use in determining a concentration of an analyte in a sample of bodily fluid, the method comprising the steps of:
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(a) forming a plurality of working electrodes on a first electrode region of a substrate; (b) forming a plurality of counter electrodes on a second electrode region of the substrate; (c) disposing a spacer layer on one of the first and the second electrode regions; (d) removing a portion of the spacer layer to define sample chamber regions; (e) folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure; and (f) separating the layered structure into a plurality of electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, and at least one sample chamber region, wherein each electrochemical sensor comprises a proximal end having a width and a distal end having a width, the distal end being configured for insertion into a sensor reader, wherein the width of the distal end is greater than the width of the proximal end. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of manufacturing a plurality of electrochemical sensors for use in determining a concentration of an analyte in a sample of bodily fluid, the method comprising the steps of:
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(a) forming a plurality of working electrodes on a first electrode region of a first substrate; (b) forming a plurality of counter electrodes on a second electrode region of the first substrate; (c) disposing a spacer layer on one of the first electrode region and the second electrode region, the spacer layer defining sample chamber regions; (d) folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure; and (e) cutting the layered structure to provide individual electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, and at least one sample chamber region, wherein at least one end of the at least one sample chamber region is defined by a cut, wherein each electrochemical sensor comprises a proximal end having a width and a distal end having a width, the distal end being configured for insertion into a sensor reader, wherein the width of the distal end is greater than the width of the proximal end. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification