Method for diagnosing non-small cell lung carcinoma

• US 8,273,701 B2
• Filed: 08/14/2006
• Issued: 09/25/2012
• Est. Priority Date: 08/16/2005
• Status: Active Grant

• Current Assignee: The Trustees of Dartmounth College (Dartmouth College)
• Original Assignee: The Trustees of Dartmounth College (Dartmouth College)
• Inventors: Robbins, David J., Yuan, Ziqiang, Goetz, John A.
• Primary Examiner(s): AEDER, SEAN E
• Application Number:
  US12/063,781
• Publication Number:
  US 20100029580A1
• Time in Patent Office: 2,234 Days
• Field of Search: None
• US Class Current: 514/1
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: G01N 33/57423 of lung
• CPC Class Codes: G06F 16/28 Databases characterised by their database models, e.g. relational or object models
• CPC Class Codes: G06F 16/33 Querying
• CPC Class Codes: G06F 16/93 Document management systems
• CPC Class Codes: G06F 2216/11 Patent retrieval

Abstract

The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.

Claims

1. A method for treating non-small cell lung carcinoma in a patient with tumor cells that are resistant to Hedgehog pathway antagonists comprising administering to a patient with non-small cell lung carcinoma tumor cells that are resistant to Hedgehog pathway antagonists, an inhibitor of Gli1 in combination with Compound 6 thereby treating the non-small cell lung carcinoma in the patient.