Medicaments containing vardenafil hydrochloride trihydrate

  • US 8,273,876 B2
  • Filed: 07/03/2003
  • Issued: 09/25/2012
  • Est. Priority Date: 07/16/2002
  • Status: Active Grant
First Claim
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1. A method for producing medicaments in the form of a coated tablet comprising vardenafil hydrochloride trihydrate and one or more excipients, said method comprising the steps ofa) providing a tablet containing vardenafil hydrochloride, irrespective of which polymorphic form or mixture of polymorphic forms of vardenafil hydrochloride is initially present in the tablet, plus one or more excipients including a disintegrant;

  • b) treating said tablet with a moistened gas for sufficient time to convert at least 90 mol % of the vardenafil hydrochloride into the trihydrate form; and

    c) coating said tablet with a coating agent.

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