Method and apparatus for utilizing amplitude-modulated pulse-width modulation signals for neurostimulation and treatment of neurological disorders using electrical stimulation
First Claim
1. A system for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a brain, the system comprising:
- means for generating an amplitude-modulated pulse-width modulation (AMPWM) signal, the AMPWM signal including a high frequency signal component and a low frequency signal component, wherein the high frequency signal component is amplitude-modulated and pulse-width modulated, wherein the high frequency signal component has a sufficiently high frequency to enable the AMPWM signal to penetrate high impedance portions of tissue located between external EEG sensors placed on a scalp and the neurological tissue of the region of the brain being stimulated, wherein the low frequency signal component is of sufficiently low frequency to provide the electrical stimulation and treatment, and wherein the low frequency signal component dynamically varies in frequency over time; and
means for transmitting the AMPWM signal from a neurostimulation device to the neurological tissue of the region of the brain being stimulated via the external EEG sensors placed on the scalp.
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Abstract
A computing device-controlled system is described for the generation of amplitude-modulated pulse-width modulation (AMPWM) signals for use in treating neurological dysfunction via cranial neurostimulation, where the AMPWM signal is specifically designed to minimize the electrical impedance of the tissues of the head. A low-frequency carrier signal is determined for the AMPWM signal by measuring EEG activity at a reference site or sites, generally corresponding with the location of suspected brain dysfunction. Carrier signal frequency is variably related to critical frequency components of the EEG power spectral density, determined from statistical analysis of amplitudes and variability, and dynamically changed as a function of time to prevent entrainment. The AMPWM signal is presented to a subject via a plurality of neurostimulation delivery modes for therapeutic use.
70 Citations
22 Claims
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1. A system for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a brain, the system comprising:
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means for generating an amplitude-modulated pulse-width modulation (AMPWM) signal, the AMPWM signal including a high frequency signal component and a low frequency signal component, wherein the high frequency signal component is amplitude-modulated and pulse-width modulated, wherein the high frequency signal component has a sufficiently high frequency to enable the AMPWM signal to penetrate high impedance portions of tissue located between external EEG sensors placed on a scalp and the neurological tissue of the region of the brain being stimulated, wherein the low frequency signal component is of sufficiently low frequency to provide the electrical stimulation and treatment, and wherein the low frequency signal component dynamically varies in frequency over time; and means for transmitting the AMPWM signal from a neurostimulation device to the neurological tissue of the region of the brain being stimulated via the external EEG sensors placed on the scalp. - View Dependent Claims (2, 3, 4, 5, 19, 20, 21)
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6. A system for providing external electrical stimulation and treatment for a disorder by electrically stimulating and treating neurological tissue of a region of a brain, the system comprising:
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a signal generator for generating an amplitude-modulated pulse-width modulation (AMPWM) signal, the generated AMPWM signal including a high frequency signal component and a low frequency signal component, wherein the high frequency signal component is amplitude-modulated and pulse-width modulated, wherein the high frequency signal component has a sufficiently high frequency to enable the generated AMPWM signal to penetrate high impedance portions of tissue located between external EEG sensors placed on a scalp and the neurological tissue of the region of the brain being stimulated, wherein the low frequency signal component is of sufficiently low frequency to provide the electrical stimulation and treatment; and a transmission device coupled to the signal generator, wherein the transmission device transmits an electrical stimulation and treatment signal from the generated AMPWM signal, and wherein the transmitted electrical stimulation and treatment signal is communicated from the neurostimulation device to the neurological tissue of the region of the brain being stimulated via the external EEG sensors placed on the scalp to electrically stimulate and treat the disorder. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 22)
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Specification