Voltammetric systems for assaying biological analytes
First Claim
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1. A method of determining a concentration of an analyte in a sample, comprising:
- contacting the sample and at least one species of a redox pair;
applying an acyclic scan to the sample,where the acyclic scan has forward and reverse scans that apply a changing voltage, andthe at least one species of the redox pair undergoes oxidation and/or reduction during the acyclic scan;
measuring current as a function of the changing voltage; and
determining a concentration of an analyte in the sample from the current.
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Abstract
The present invention relates to systems, methods, and devices for determining the concentration of an analyte in a sample. The use of linear, cyclic, or acyclic voltammetric scans and/or semi-integral, derivative, or semi-derivative data treatment may provide for increased accuracy when determining the concentration of an analyte in a sample. Hematocrit compensation in combination with the data treatments may reduce the hematocrit effect with regard to a glucose analysis in whole blood. In another aspect, fast scan rates may reduce the hematocrit effect.
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38 Claims
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1. A method of determining a concentration of an analyte in a sample, comprising:
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contacting the sample and at least one species of a redox pair; applying an acyclic scan to the sample, where the acyclic scan has forward and reverse scans that apply a changing voltage, and the at least one species of the redox pair undergoes oxidation and/or reduction during the acyclic scan; measuring current as a function of the changing voltage; and determining a concentration of an analyte in the sample from the current. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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Specification