Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent

  • US 8,288,434 B2
  • Filed: 06/03/2009
  • Issued: 10/16/2012
  • Est. Priority Date: 06/05/2008
  • Status: Active Grant
First Claim
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1. An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the combined concentration of water and the organic solvent is sufficient to provide a suspension of a benzoyl peroxide in a saturated solution of benzoyl peroxide, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w.

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