Controlled release and taste masking oral pharmaceutical composition
DC CAFCFirst Claim
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1. A controlled release oral pharmaceutical composition comprising:
- (1) a tablet core comprising;
a) budesonide in an amount effective for treatment of inflammatory bowel disease in the gastrointestinal tract,b) stearic acid;
c) lecithin; and
d) hydroxypropyl cellulose; and
(2) a gastro-resistant coating on said tablet core, said coating comprising at least one methacrylic acid polymer.
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Abstract
Controlled release and taste masking compositions containing one or more active principles inglobated in a three-component matrix structure, i.e. a structure formed by successive amphiphilic, lipophilic or inert matrices and finally inglobated or dispersed in hydrophilic matrices. The use of a plurality of systems for the control of the dissolution of the active ingredient modulates the dissolution rate of the active ingredient in aqueous and/or biological fluids, thereby controlling the release kinetics in the gastrointestinal tract.
37 Citations
4 Claims
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1. A controlled release oral pharmaceutical composition comprising:
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(1) a tablet core comprising; a) budesonide in an amount effective for treatment of inflammatory bowel disease in the gastrointestinal tract, b) stearic acid; c) lecithin; and d) hydroxypropyl cellulose; and (2) a gastro-resistant coating on said tablet core, said coating comprising at least one methacrylic acid polymer. - View Dependent Claims (2, 3, 4)
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Specification