Process for stereoselective synthesis of lamivudine
First Claim
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1. A process for stereoselective synthesis of Lamivudine, comprising the following steps:
- (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and
(b) deprotecting the intermediate of formula (II) to obtain Lamivudine,wherein the reaction scheme is as follows;
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Abstract
The present invention discloses a process for stereoselective synthesis of Lamivudine comprising the following steps: (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine.
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11 Claims
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1. A process for stereoselective synthesis of Lamivudine, comprising the following steps:
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(a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and (b) deprotecting the intermediate of formula (II) to obtain Lamivudine, wherein the reaction scheme is as follows; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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