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Process for stereoselective synthesis of lamivudine

  • US 8,304,540 B2
  • Filed: 11/17/2009
  • Issued: 11/06/2012
  • Est. Priority Date: 05/18/2007
  • Status: Expired due to Fees
First Claim
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1. A process for stereoselective synthesis of Lamivudine, comprising the following steps:

  • (a) performing a glycosylation reaction between the compound of formula (I) and cytosine or protected cytosine, and separating the reaction product by recrystallization to obtain the intermediate of formula (II); and

    (b) deprotecting the intermediate of formula (II) to obtain Lamivudine,wherein the reaction scheme is as follows;

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