Methods and apparatus for analyzing samples and collecting sample fractions

  • US 8,305,581 B2
  • Filed: 12/03/2010
  • Issued: 11/06/2012
  • Est. Priority Date: 12/05/2007
  • Status: Active Grant
First Claim
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1. A method of detecting and collecting one or more sample components within a sample stream in a chromatography system during a chromatographic run comprising:

  • generating a first signal during the chromatographic run from at least one destructive detector, including at least one evaporative particle detector;

    generating a second signal during the chromatographic run from at least one non-destructive detector,wherein said non-destructive detector monitors a whole absorbance spectrum or a portion thereof comprising more than one wavelength, and wherein said second signal comprises at least one response value from each of the more than one wavelength; and

    collecting the one or more components from the stream in a fraction collector during the chromatographic run in response to a change in at least one of said signals during said chromatographic run.

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