Lighting design of high quality biomedical devices

• US 8,309,940 B2
• Filed: 05/30/2012
• Issued: 11/13/2012
• Est. Priority Date: 01/23/2009
• Status: Active Grant

• Current Assignee: Lumencor, Inc.
• Original Assignee: Lumencor, Inc.
• Inventors: Jaffe, Claudia B., Jaffe, Steven M., Conner, Arlie R.
• Primary Examiner(s): Porta, David
• Assistant Examiner(s): Maupin, Hugh H
• Application Number:
  US13/484,031
• Publication Number:
  US 20120236585A1
• Time in Patent Office: 167 Days
• Field of Search: 250/459.1
• US Class Current: 250/459.1
• CPC Class Codes: G01J 1/58 using luminescence generated by light
• CPC Class Codes: G01J 3/10 Arrangements of light sources specially adapted for spectrometry or colorimetry
• CPC Class Codes: G01N 21/64 Fluorescence; Phosphorescence
• CPC Class Codes: G02B 6/0003 the light guides being doped with fluorescent agents

Abstract

The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today'"'"'s commercial, academic and clinical biotech labs.

Claims

1. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument wherein the solid state light engine is capable of emitting narrowband light exceeding 500 mW per color with intensities up to 10 W/cm².

5. The solid state light engine of claim 1, in combination with an optical instrument coupled to the optical output element, wherein the optical instrument is selected from the group consisting of:

a sensor;

an optical probe;

a microscope;

a liquid light guide;

a fiber optic cable;

a micro fluidic chip; and

a micro titer plate.

6. The solid state light engine of claim 1, wherein each color can be switched independently.

10. The solid state light engine of claim 1, wherein the luminescent material includes one or more of rare earths, transition metals, and donor-acceptor pairs.

11. The solid state light engine of claim 1, further comprising at least one laser diode for emitting laser light.

12. The solid state light engine of claim 1, wherein output color is compatible with triggering by one or more of TTL, RS232, and USB.

2. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein the solid state light engine can be pulsed on and off rapidly to enable time-based detection methods.

3. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein the solid state light engine can be pulsed on and off at a frequency greater than 2 kHz.

4. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein the solid state light engine can be pulsed on and off at a frequency of about 5 kHz.

7. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein each color can be switched independently in 30 μ

s or less.

8. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein the luminescent color is green, the first color is red, the second color is blue, and the third color is cyan.

9. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

a fourth LED light module wherein the fourth LED light module includes at least a fourth LED adapted to emit fourth light of a fourth color different than the first color, the second color, the third color, and the luminescent color; and

wherein the plurality of dichroic elements is adapted to direct each of the luminescent light, the first light, the second light, the third light, and the fourth light toward the optical output element for transmission to said optical instrument.

13. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein the solid state light engine is adapted for simultaneous excitation of multiple fluorescent tags.

14. A solid-state light engine comprising:

a lamp which includes a rod and a solid state light source, wherein in the rod includes a narrowband luminescent material, and wherein the solid state light source is adapted to emit light to excite the narrowband luminescent material such that the narrowband luminescent material emits luminescent light of a luminescent color by spontaneous emission;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, the second light and the third light into an output light beam; and

an optical output element adapted to couple the output light beam to an optical instrument; and

wherein the solid state light engine is adapted for rapid serial excitation of multiple different fluorescent tags in microsecond timeframes.

15. A solid-state light engine comprising:

a lamp which includes a rod and an LED light source, wherein in the rod includes a luminescent material, and wherein the LED light source is adapted to emit light to excite the luminescent material such that the luminescent material emits luminescent light of a luminescent color;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, and the second light into an output light beam;

an optical output element adapted to couple the output light beam to a microscope; and

wherein the solid state light engine is capable of emitting narrowband light exceeding 500 mW per color.

18. The solid state light engine of claim 15, wherein the luminescent color is green, the first color is red, and the second color is blue.

19. The solid state light engine of claim 15, further comprising:

a third LED light module wherein the third LED light module includes at least a third LED adapted to emit third light of a third color different than the first color, the second color, and the luminescent color; and

wherein the plurality of dichroic elements is adapted to direct each of the luminescent light, the first light, the second light, and the third light toward the optical output element for transmission to said optical instrument.

20. The solid state light engine of claim 15, wherein output color is compatible with triggering by one or more of TTL, RS232, and USB.

16. A solid-state light engine comprising:

a lamp which includes a rod and an LED light source, wherein in the rod includes a luminescent material, and wherein the LED light source is adapted to emit light to excite the luminescent material such that the luminescent material emits luminescent light of a luminescent color;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, and the second light into an output light beam;

an optical output element adapted to couple the output light beam to a microscope; and

wherein the solid state light engine can be pulsed on and off at a frequency greater than 2 kHz.

17. A solid-state light engine comprising:

a lamp which includes a rod and an LED light source, wherein in the rod includes a luminescent material, and wherein the LED light source is adapted to emit light to excite the luminescent material such that the luminescent material emits luminescent light of a luminescent color;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, and the second light into an output light beam;

an optical output element adapted to couple the output light beam to a microscope; and

wherein each color can be switched independently in 30 μ

s or less.

21. A solid-state light engine comprising:

a lamp which includes a rod and an LED light source, wherein in the rod includes a luminescent material, and wherein the LED light source is adapted to emit light to excite the luminescent material such that the luminescent material emits luminescent light of a luminescent color;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, and the second light into an output light beam;

an optical output element adapted to couple the output light beam to a microscope; and

wherein the solid state light engine can be adapted for simultaneous excitation of multiple fluorescent tags.

22. A solid-state light engine comprising:

a lamp which includes a rod and an LED light source, wherein in the rod includes a luminescent material, and wherein the LED light source is adapted to emit light to excite the luminescent material such that the luminescent material emits luminescent light of a luminescent color;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit first light of a first color different than the luminescent color;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit second light of a second color different than the first color and the luminescent color;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, and the second light into an output light beam;

an optical output element adapted to couple the output light beam to a microscope; and

wherein the solid state light engine can be adapted for rapid serial excitation of multiple different fluorescent tags in microsecond timeframes.

23. A solid-state light engine comprising:

a lamp which includes a luminescent rod and a solid state light source, wherein in the luminescent rod includes a luminescent material, and wherein the solid state light source is adapted to emit light to excite the luminescent material such that the luminescent material emits green light;

a first LED light module, wherein the first LED light module includes at least a first LED adapted to emit red light;

a second LED light module, wherein the second LED light module includes at least a second LED adapted to emit blue light;

a plurality of dichroic elements adapted to direct each of the luminescent light, the first light, and the second light into an output light beam;

an optical output element adapted to couple the output light beam to a microscope.

24. The solid state light engine of claim 23, wherein the solid state light engine can be pulsed on and off at a frequency greater than 2 kHz.

25. The solid state light engine of claim 23, wherein each color can be switched independently in 30 μ

s or less.

26. The solid state light engine of claim 23, wherein output color is compatible with triggering by one or more of TTL, RS232, and USB.

27. The solid state light engine of claim 23, wherein the solid state light source is an LED light source.

28. The solid state light engine of claim 23, further comprises one or more additional led light sources which produce one or more additional colors of light selected from UV, Cyan, Teal and Orange.