Arrhythmia discrimination using ECG's sensed from multiple implanted electrodes

• US 8,321,002 B2
• Filed: 02/15/2011
• Issued: 11/27/2012
• Est. Priority Date: 05/09/2005
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhang, Yi, Ricci, Carlos A., Stahmann, Jeffrey E., McCabe, Aaron, Meyer, Scott, Yu, Yinghong
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US13/027,608
• Publication Number:
  US 20110137192A1
• Time in Patent Office: 651 Days
• Field of Search: 600/512
• US Class Current: 600/512
• CPC Class Codes: A61B 5/341 Vectorcardiography [VCG]
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal

Abstract

Cardiac monitoring and/or stimulation methods and systems provide for monitoring, diagnosing, defibrillation and pacing therapies, or a combination of these capabilities, including cardiac systems incorporating or cooperating with neuro-stimulating devices, drug pumps, or other therapies. Embodiments of the present invention relate generally to implantable medical devices employing automated cardiac activation sequence monitoring and/or tracking for arrhythmia discrimination. Embodiments of the invention are directed to devices and methods involving sensing a plurality of composite cardiac signals using a plurality of implantable electrodes. A source separation is performed using the sensed plurality of composite cardiac signals and the separation produces one or more cardiac signal vectors associated with one or more cardiac activation sequences that is indicative of ischemia. A change of the one or more cardiac signal vectors is detected using the one or more cardiac signal vectors. Cardiac arrhythmias are discriminated using the one or more cardiac signal vectors.

Claims

1. A processor-implemented method, comprising:

sensing a plurality of composite cardiac signals at a plurality of patient-internal locations for a multiplicity of cardiac cycles;

performing a plurality of source separations using the sensed composite cardiac signals;

producing a cardiac signal vector indicative of a cardiac activation sequence of an area of the patient'"'"'s heart based on each of the plurality of source separations;

measuring an orientation of the cardiac signal vectors relative to a baseline established for the patient;

detecting ventricular tachycardia (VT) based on the cardiac signal vector orientation measurements; and

in response to detecting VT;

determining variation of the cardiac signal vector orientation measurements, wherein determining the variation of the cardiac signal vector orientation measurements comprises;

performing a subsequent source separation using sensed composite cardiac signals for each of a plurality of consecutive cardiac cycles after VT is detected;

producing a subsequent cardiac signal vector based on each of the subsequent source separations;

measuring an orientation of each subsequent cardiac signal vector relative to the baseline; and

determining the variation of the subsequent cardiac signal vector orientation measurements; and

discriminating between polymorphic ventricular tachycardia (PVT) and monomorphic ventricular tachycardia (MVT) based on the variation of the cardiac signal vector orientation measurements, wherein at least some of the method is implemented by a processor.

2. The method according to claim 1, wherein determining the variation comprises determining the variation of cardiac signal vector orientation measurements for a plurality of consecutive cardiac cycles subsequent to VT detection.

3. The method according to claim 1, wherein discriminating between PVT and MVT comprises:

comparing the variation to a pre-determined value; and

discriminating between PVT and MVT based on the comparison.

4. The method according to claim 1, wherein discriminating between PVT and MVT comprises:

comparing the variation to a pre-determined value;

determining presence of PVT if the variation is greater than the pre-determined value; and

determining presence of MVT if the variation is less than the pre-determined value.

5. The method according to claim 1, comprising establishing the baseline by performing an initial source separation using sensed composite cardiac signals.

6. The method according to claim 1, comprising establishing the baseline using clinical data.

7. The method according to claim 1, further comprising differentiating between left ventricular tachycardia (LVT) and right ventricular tachycardia (RVT) in response to detecting MVT.

8. The method according to claim 7, comprising:

determining a shift in orientation of axes of the cardiac signal vectors relative to the baseline; and

differentiating between LVT and RVT based on a direction of the shift of the cardiac signal vector axes.

9. The method according to claim 7, comprising:

determining a directional shift of cardiac signal vector axes relative to the baseline;

determining whether the directional shift of the cardiac signal vector axes falls within a pre-determined LVT range or a pre-determined RVT range;

identifying the VT as LVT in response to the directional shift falling within the LVT range; and

identifying the VT as RVT in response to the directional shift falling within the RVT range.

10. An apparatus, comprising:

a plurality of implantable electrodes configured for sensing composite cardiac signals over a multiplicity of cardiac cycles;

a housing configured for implantation in a patient; and

a processor provided in the housing and coupled to the plurality of implantable electrodes, the processor configured to perform a plurality of source separations using the sensed composite cardiac signals, produce a cardiac signal vector indicative of a cardiac activation sequence of an area of the patient'"'"'s heart based on each of the plurality of source separations, measure an orientation of the cardiac signal vectors relative to a baseline established for the patient, detect ventricular tachycardia (VT) based on the cardiac signal vector orientation measurements, and, if VT is detected, discriminate between polymorphic ventricular tachycardia (PVT) and monomorphic ventricular tachycardia (MVT) based on the cardiac signal vector orientation measurements;

wherein the processor is configured to perform a subsequent source separation using sensed composite cardiac signals for each of a plurality of consecutive cardiac cycles after VT is detected, produce a subsequent cardiac signal vector based on each of the subsequent source separations, measure an orientation of each subsequent cardiac signal vector relative to the baseline, and determine the variation of the subsequent cardiac signal vector orientation measurements.

11. The apparatus according to claim 10, wherein the processor is configured to determine the variation of cardiac signal vector orientation measurements for a plurality of consecutive cardiac cycles subsequent to VT detection.

12. The apparatus according to claim 10, wherein the processor is configured to compare the variation to a pre-determined value, and discriminate between PVT and MVT based on the comparison.

13. The apparatus according to claim 10, wherein the processor is configured to compare the variation to a pre-determined value, determine presence of PVT if the variation is greater than the pre-determined value, and determine presence of MVT if the variation is less than the pre-determined value.

14. The apparatus according to claim 10, wherein the processor is configured to establish the baseline by performing an initial source separation using sensed composite cardiac signals.

15. The apparatus according to claim 10, wherein the processor is configured to use a baseline based on clinical data.

16. The apparatus according to claim 10, wherein the processor is configured to differentiate between left ventricular tachycardia (LVT) and right ventricular tachycardia (RVT) in response to detecting MVT.

17. The apparatus according to claim 16, wherein the processor is configured to determine a shift in orientation of axes of the cardiac signal vectors relative to the baseline, and differentiate between LVT and RVT based on a direction of the shift of the cardiac signal vector axes.

18. The apparatus according to claim 16, wherein the processor is configured to determine a directional shift of cardiac signal vector axes relative to the baseline, determine whether the directional shift of the cardiac signal vector axes falls within a pre-determined LVT range or a pre-determined RVT range, identify the VT as LVT in response to the directional shift falling within the LVT range, and identify the VT as RVT in response to the directional shift falling within the RVT range.