Linear polyol stabilized polyfluoroacrylate compositions
DCFirst Claim
1. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt loaded with a stabilizing amount of a linear sugar alcohol by slurrying in a solution the linear sugar alcohol with the crosslinked cation exchange polymer salt, wherein the stabilizing amount of the linear sugar alcohol is from about 10 wt. % to about 35 wt. % based on the total weight of the composition, and the crosslinked cation exchange polymer salt comprising structural units of Formulae 1 and 2, Formulae 1 and 3, or Formulae 1, 2, and 3, wherein Formula 1, Formula 2, and Formula 3 have the following structures:
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Abstract
The present invention is directed to compositions of a linear polyol and a salt of a crosslinked cation exchange polymer comprising a fluoro group and an acid group. These compositions are useful to bind potassium in the gastrointestinal tract.
72 Citations
78 Claims
- 1. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt loaded with a stabilizing amount of a linear sugar alcohol by slurrying in a solution the linear sugar alcohol with the crosslinked cation exchange polymer salt, wherein the stabilizing amount of the linear sugar alcohol is from about 10 wt. % to about 35 wt. % based on the total weight of the composition, and the crosslinked cation exchange polymer salt comprising structural units of Formulae 1 and 2, Formulae 1 and 3, or Formulae 1, 2, and 3, wherein Formula 1, Formula 2, and Formula 3 have the following structures:
- 2. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt and a linear sugar alcohol, wherein the cation exchange polymer salt is loaded with the linear sugar alcohol by slurrying in a solution the linear sugar alcohol with the crosslinked cation exchange polymer salt, the crosslinked cation exchange polymer salt comprising structural units of Formulae 1 and 2, Formulae 1 and 3, or Formulae 1, 2, and 3, wherein Formula 1, Formula 2, and Formula 3 have the following structures:
- 7. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt and from about 10 wt. % to about 35 wt. % of a linear sugar alcohol based on the total weight of the composition, wherein a crosslinked cation exchange polymer is a reaction product of a polymerization mixture comprising monomers of either (i) Formulae 11 and 22, (ii) Formulae 11 and 33, or (iii) Formulae 11, 22, and 33, the crosslinked cation exchange polymer is converted to the crosslinked cation exchange polymer salt, and the crosslinked cation exchange polymer salt is slurried in a solution of the linear sugar alcohol, wherein Formula 11, Formula 22, and Formula 33 have the following structures:
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8. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt and a linear sugar alcohol, wherein a crosslinked cation exchange polymer is a reaction product of a polymerization mixture comprising monomers of either (i) Formulae 11 and 22, (ii) Formulae 11 and 33, or (iii) Formulae 11, 22, and 33, the crosslinked cation exchange polymer is converted to the crosslinked cation exchange polymer salt, and the crosslinked cation exchange polymer salt is slurried in a solution of the linear sugar alcohol;
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the linear sugar alcohol is in an amount sufficient to reduce the release of fluoride ion from the polymer salt upon storage as compared to an otherwise identical composition containing no linear sugar alcohol at the same temperature and storage time, and wherein there is no more than 1000 ppm of inorganic fluoride in the composition after storage, and Formula 11, Formula 22, and Formula 33 have the following structures; - View Dependent Claims (41, 42, 43, 44, 54, 57, 58, 59, 60)
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- 61. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt in bead form having a stabilizing amount of a linear sugar alcohol loaded onto the polymer salt by slurrying in a solution the linear sugar alcohol with the crosslinked cation exchange polymer salt, wherein the stabilizing amount of the linear sugar alcohol is from about 10 wt. % to about 35 wt. % based on the total weight of the composition, the crosslinked cation exchange polymer salt comprising structural units of Formulae 1 and 2, Formulae 1 and 3, or Formulae 1, 2, and 3, wherein Formula 1, Formula 2, and Formula 3 have the following structures:
- 69. A pharmaceutical composition comprising a crosslinked cation exchange polymer salt in bead form having a linear sugar alcohol loaded onto the polymer salt by slurrying in a solution the linear sugar alcohol with the crosslinked cation exchange polymer salt, the crosslinked cation exchange polymer comprising structural units of Formulae 1 and 2, Formulae 1 and 3, or Formulae 1, 2, and 3, wherein Formula 1, Formula 2, and Formula 3 have the following structures:
Specification