Pellet formulation for the treatment of the intestinal tract

  • US 8,337,886 B2
  • Filed: 09/23/2008
  • Issued: 12/25/2012
  • Est. Priority Date: 07/30/1997
  • Status: Expired due to Fees
First Claim
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1. A controlled release pellet formulation for treatment of the intestinal tract, said formulation comprising a core comprising:

  • 1) a homogeneously dispersed pharmaceutically active compound in a non gel-forming polymer matrix and

         2) an enteric coating,wherein the non gel-forming polymer matrix is essentially insoluble in the intestinal tract and permeable to intestinal fluid made by the process comprising;

    mixing the pharmaceutically active compound and the non gel-forming polymer matrix;

    scattering in a pharmaceutically tolerable additive; and

    extruding a moist mass of the matrix-forming polymer and the active compound.

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