In-situ formation of a valve

• US 8,348,999 B2
• Filed: 02/13/2012
• Issued: 01/08/2013
• Est. Priority Date: 01/08/2007
• Status: Active Grant

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Kheradvar, Arash, Gharib, Morteza
• Primary Examiner(s): McDermott, Corrine M
• Assistant Examiner(s): LAUER, CHRISTINA C
• Application Number:
  US13/372,392
• Publication Number:
  US 20120143319A1
• Time in Patent Office: 330 Days
• Field of Search: 623/2.11, 623/2.12, 623/2.13, 623/2.14, 623/2.15, 623/2.16, 623/2.17, 623/2.18, 623/1.19, 623/1.26, 623/23.68, 623/1.24, 606/191, 606/192, 606/194
• US Class Current: 623/2.11
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2/2436 Deployment by retracting a sheath
• CPC Class Codes: A61F 2/2439 Expansion controlled by filaments
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0066 stapled
• CPC Class Codes: A61F 2230/0054 V-shaped

Abstract

The present invention satisfies the long felt need for a more compact and durable valve which may be formed in situ. The present invention provides a self-deployable valve system, a method of delivery, and a method of manufacturing for the self-deployable valve system. The present invention delivers the necessary components for forming a complete valve system in situ. The collapsed subcomponents of the system lack any functional characteristics commonly associated with a valve before being expanded. However, once expanded, the system is transformed into a competent valve for use in a wide variety of applications.

Claims

1. A method for forming a valve in situ, comprising acts of:

delivering an expandable component attached to a distal end of a sheet component to a target area;

expanding the expandable component;

positioning the sheet component into the expandable component, such that the positioning induces the sheet component to form a functional valve within the expandable component; and

wherein the act of expanding the expandable component induces the sheet component to position into the expandable component thereby forming the functional valve.

2. The method for forming a valve in situ as in claim 1, further comprising an act of selectively suturing a proximal end of the sheet.

3. The method for forming a valve in situ as in claim 1, wherein the sheet component includes a proximal end and wherein at least one link is attached to at least one point of the proximal end of the sheet component by folding, sowing, pinching, suturing, gluing, chemical sealing, mechanically fastening, heat sealing, and any combination thereof.

4. The method for forming a valve in situ as in claim 1, further comprising an act of replacing a preexisting natural valve or an artificial valve.

5. A method for manufacturing a valve formed in situ comprising acts of:

attaching at least a portion of an expandable component to a distal end of a sheet component;

fixedly attaching a plurality of portions of a proximal end of the sheet component to itself; and

adjoining the distal portion of the sheet component to the distal end of the expandable component, such that expansion of the expandable component draws the sheet component into the expandable component to form a valve.

6. The method for manufacturing a valve in situ as in claim 5, wherein the distal end of the sheet component is adjoined to a distal end of the expandable component by a fiber.

7. A method for forming a valve in situ comprising acts of:

placing a compliant sheet component in contact with a plurality of prongs of an expandable component;

using the prongs to pinch the proximal end at a point of contact between each of the prongs and the sheet;

expanding the sheet component and expandable component; and

inverting the sheet component to forth a valve in situ, wherein the act of inverting the sheet component is triggered by expansion of the expandable component.

8. A method for forming a valve in situ comprising acts of:

placing a sheet component in contact with a plurality of apexes of an expandable component;

flustering the proximal end of the sheet component to itself in at least two locations;

expanding the sheet component and expandable component; and

turning the sheet component inside out thereby forming a valve in situ, wherein the act of turning the sheet component inside out is triggered by expansion of the expandable component.