Controlled release formulations of levodopa and uses thereof

  • US 8,377,474 B2
  • Filed: 12/26/2008
  • Issued: 02/19/2013
  • Est. Priority Date: 12/28/2007
  • Status: Active Grant
First Claim
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1. A controlled release oral solid formulation of levodopa comprising:

  • a. a controlled release component comprising levodopa, a decarboxylase inhibitor and one or more rate controlling excipients,b. a carboxylic acid component comprising a carboxylic acid that is not levodopa or the decarboxylase inhibitor and one or more rate controlling excipients, andc. an immediate release component comprising levodopa and a decarboxylase inhibitor,wherein the carboxylic acid component of (b) is a distinct component and is coated with an enteric polymer; and

    wherein the controlled release component (a), the immediate release component (c) and the carboxylic acid component (b) comprise beads or granules.

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