Method and device for displaying predicted volume of influence with patient-specific atlas of neural tissue
First Claim
1. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
- receiving imaging data representing the anatomy of the patient'"'"'s neural tissue;
creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with an atlas that is not specific to the patient and that identifies neural structures in neural tissue;
calculating, by a computer processor, an electric field in the patient'"'"'s neural tissue, the electric field to be generated by the electrode;
calculating, by the processor and based on the determined electric field, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and
displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue.
0 Assignments
0 Petitions
Accused Products
Abstract
This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.
161 Citations
34 Claims
-
1. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with an atlas that is not specific to the patient and that identifies neural structures in neural tissue; calculating, by a computer processor, an electric field in the patient'"'"'s neural tissue, the electric field to be generated by the electrode; calculating, by the processor and based on the determined electric field, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue by registering the imaging data with a non-patient-specific atlas that identifies neural structures in neural tissue; calculating, by a computer processor, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue; wherein; the step of registering the imaging data with the non-patient-specific atlas comprises performing a transformation of the non-patient-specific atlas; and the transformation is performed by; performing a first transformation having a first dimensional basis; and performing a second transformation having a second higher dimensional basis than the first dimensional basis, the second transformation including the use of vector fields generated using a mismatch between the non-patient-specific atlas and the anatomy of the patient'"'"'s neural tissue as represented by the imaging data. - View Dependent Claims (24)
-
-
25. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue by registering the imaging data with a non-patient-specific atlas that identifies neural structures in neural tissue; calculating, by a computer processor, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue; wherein; the step of registering the imaging data with the non-patient-specific atlas comprises performing a transformation of the imaging data; and the transformation is performed by; performing a first transformation having a first dimensional basis; and performing a second transformation having a second higher dimensional basis than the first dimensional basis, the second transformation including the use of vector fields generated using a mismatch between the non-patient-specific atlas and the anatomy of the patient'"'"'s neural tissue as represented by the imaging data. - View Dependent Claims (26)
-
-
27. A computer system comprising:
-
(a) a processor configured to receive imaging data representing the anatomy of a patient'"'"'s neural tissue; (b) a memory device in which an atlas that is not specific to the patient and that identifies neural structures in neural tissue is stored; and (c) a display screen; wherein the processor is configured to perform steps comprising; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with the atlas that is not specific to the patient; calculating an electric field in the patient'"'"'s neural tissue, the electric field to be generated by an electrode inserted inside the patient'"'"'s neural tissue; calculating based on the determined electric field, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying, on the display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue.
-
-
28. A non-transitory computer-readable storage medium comprising instructions for:
-
receiving imaging data representing the anatomy of a patient'"'"'s neural tissue; accessing an atlas that is not specific to the patient and that identifies neural structures in neural tissue; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with the atlas that is not specific to the patient; calculating an electric field in the patient'"'"'s neural tissue, the electric field to be generated by an electrode inserted inside the patient'"'"'s neural tissue; calculating based on the determined electric field, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying the predicted volume of influence together with the patient-specific atlas of neural tissue.
-
-
29. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with an atlas that is not specific to the patient and that identifies neural structures in neural tissue, the registering including performing a transformation of the atlas that is not specific to the patient; calculating, by a computer processor, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue; wherein; the transformation is performed by; performing a first transformation having a first dimensional basis; and performing a second transformation having a second higher dimensional basis than the first dimensional basis; and performing the second transformation includes the use of vector fields generated using a mismatch between the atlas that is not specific to the patient and the anatomy of the patient'"'"'s neural tissue as represented by the imaging data. - View Dependent Claims (30)
-
-
31. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with an atlas that is not specific to the patient and that identifies neural structures in neural tissue, the registering including performing a transformation of the imaging data; calculating, by a computer processor, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue; wherein; the transformation is performed by; performing a first transformation having a first dimensional basis; and performing a second transformation having a second higher dimensional basis than the first dimensional basis; performing the second transformation includes the use of vector fields generated using a mismatch between the atlas that is not specific to the patient and the anatomy of the patient'"'"'s neural tissue as represented by the imaging data. - View Dependent Claims (32)
-
-
33. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with an atlas that is not specific to the patient and that identifies neural structures in neural tissue; calculating, by a computer processor, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue; wherein the calculating includes using electric potential distribution.
-
-
34. A method of displaying a predicted volume of influence by an electrode inserted inside a patient'"'"'s neural tissue, the method comprising:
-
receiving imaging data representing the anatomy of the patient'"'"'s neural tissue; creating a patient-specific atlas of neural tissue that is specific to the patient by registering the imaging data with an atlas that is not specific to the patient and that identifies neural structures in neural tissue; calculating, by a computer processor, a predicted volume of influence for the electrode inserted inside the patient'"'"'s neural tissue, wherein the predicted volume of influence is a representation of estimated electrode activated neural tissue; and displaying, on a display screen, the predicted volume of influence together with the patient-specific atlas of neural tissue; wherein the calculating includes using tissue conductivity data.
-
Specification