Process for hydrophilizing surfaces of fluidic components and systems

• US 8,394,338 B2
• Filed: 04/14/2005
• Issued: 03/12/2013
• Est. Priority Date: 04/26/2004
• Status: Active Grant

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Werkl, Dietmar, Leiner, Marco, Ziegler, Werner, Weis, Lonie
• Primary Examiner(s): Xu, Robert
• Application Number:
  US11/106,143
• Publication Number:
  US 20050255579A1
• Time in Patent Office: 2,889 Days
• Field of Search: None
• US Class Current: 422/500
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/161 Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B05D 2201/02 Polymeric substrate
• CPC Class Codes: B05D 3/14 by electrical means
• CPC Class Codes: B05D 3/142 Pretreatment
• CPC Class Codes: B05D 3/144 of polymeric substrates
• CPC Class Codes: B05D 5/04 to obtain a surface receptive to ink or other liquid B05D5/02, B41M5/52 take precedence
• CPC Class Codes: B05D 7/22 to internal surfaces, e.g. of tubes
• CPC Class Codes: B05D 7/222 of pipes
• CPC Class Codes: B05D 7/227 of containers, cans or the like
• CPC Class Codes: G01N 33/4915 using flow cells flow cytometry G01N15/14
• CPC Class Codes: Y10T 436/208339 Fuel/air mixture or exhaust gas analysis

Abstract

A process for producing a film of a hydrophilic polymer on the inner surfaces of a fluidic component is provided comprising subjecting the inner surfaces of the fluidic component to a physicochemical pre-treatment, contacting the inner surfaces of the fluidic component with a solution of the hydrophilic polymer, replacing the solution of the hydrophilic polymer with a gaseous medium in such a manner that firstly the inner surfaces of the fluidic component remain wetted with part of the polymer solution, and removing the solvent to produce a film of the hydrophilic polymer on the inner surfaces of the fluidic component. The hydrophilic polymer used has a surface wettability for aqueous solutions which is higher than the surface wettability of the inner surfaces of the fluidic component itself.

Claims

1. A fluidic system for transporting liquids comprising two or more fluidic components assembled so as to be in fluid communication, each of said fluidic components having at least one fluid-conveying surface, wherein a film of the same hydrophilic polymer is present on each fluid-conveying surface of each fluidic component, said film having a surface wettability greater than the wettability of at least one of said fluid-conveying surfaces of said fluidic components in the absence of said film, and wherein at least one of said fluidic components has a fluid-conveying surface that adjoins a fluid-conveying surface of another of said fluidic components, each of said adjoining fluid-conveying surfaces of said two fluidic components being provided with a continuous film of the same hydrophilic polymer.

13. A process for the production of a fluidic system of claim 1, wherein said two or more fluidic components are assembled to form the fluidic system;

and the process steps i) to iii) hereafter, are carried out on the assembled fluidic system;

i) the liquid conveying surfaces of the assembled fluidic system are brought into contact with a solution of the hydrophilic polymer,

ii) the solution of the hydrophilic polymer is replaced by a gaseous medium in such a manner that first the liquid conveying surfaces of the assembled fluidic system remain wetted with part of the solution of the hydrophilic polymer, and

iii) a film of the hydrophilic polymer remains on the liquid conveying surfaces of the assembled fluidic system by removing the solvent,

and wherein at least one of said assembled fluidic components has a fluid-conveying surface that adjoins a fluid-conveying surface of another of said assembled fluidic components, said adjoining fluid-conveying surfaces of said two assembled fluidic components being provided with a continuous film of the same hydrophilic polymer.

17. The fluidic system of claim 1 wherein said fluidic components are selected from the group consisting of a channel, tube, pipe, valve, distributor, coupling element, liquid receiving device, nipple, liquid-conveying area of a sensory element or liquid container.

18. The fluidic system of claim 1, wherein the film of the hydrophilic polymer has a thickness of between about 0.01 and about 50 μ

m.

19. The fluidic system of claim 18, wherein said thickness is between about 0.01 and about 10 μ

m.

20. The fluidic system of claim 19, wherein said thickness is between about 0.01 and about 5 μ

m.

21. The fluidic system of claim 1 wherein the hydrophilic polymer is a block copolymer with hydrophilic regions and hydrophobic regions.

22. The fluidic system of claim 21 wherein the hydrophilic polymer is a polyether-polyurethane copolymer.

2. An analytical system for determining at least one physical or chemical parameter of a liquid, said system comprising at least one sensory element for determining at least one physical or chemical parameter of the liquid, and at least one fluidic component for transporting liquids to the sensory element and/or from the sensory element, wherein said at least one sensory element has a fluid-conveying surface that adjoins a fluid-conveying surface of said at least one fluidic component, wherein a continuous film of the same hydrophilic polymer is present on each of said adjoining fluid-conveying surfaces, said film having a surface wettability greater than the wettability of at least one of said fluid-conveying surfaces in the absence of said film, and wherein said fluid conveying surface of said at least one sensory element comes into direct contact with the sample to be examined.

3. The analytical system of claim 2, wherein the liquid to be analysed is a physiological liquid.

4. The analytical system of claim 3, wherein the physiological liquid is selected from blood, serum, plasma, urine, or combinations thereof.

5. The analytical system of claim 2 wherein the analytical system contains a plurality of sensory elements.

6. The analytical system of claim 5, wherein the plurality of sensory elements are combined within at least one sensory module, and wherein the sensory module is characterized to determine various physical and/or chemical parameters of a liquid.

7. The analytical system of claim 2, wherein the fluidic component is a channel, tube, pipe, valve, distributor, coupling element, liquid receiving device, nipple, or liquid-conveying area of a sensory element or liquid container.

8. The analytical system of claim 2, wherein the film of the hydrophilic polymer has a thickness of between about 0.01 and about 50 μ

m.

9. The analytical system of claim 8, wherein said thickness is between about 0.01 and about 10 μ

m.

10. The analytical system of claim 8, wherein said thickness is between about 0.01 and about 5 μ

m.

11. The analytical system of claim 2, wherein the hydrophilic polymer is a block copolymer with hydrophilic regions and hydrophobic regions.

12. The analytical system of claim 2, wherein the hydrophilic polymer is a polyether-polyurethane copolymer.

14. A sensory module system for determination of at least one physical and/or chemical parameter of a liquid sample, said sensory module system comprising a plurality of sensory elements and a fluidic partial system for transporting liquid to and/or from a sensory element wherein a film of the same hydrophilic polymer is present both on liquid conveying surfaces of at least one said sensory element and on each liquid conveying surface of the said fluidic partial system, and wherein said film consists essentially of polymer molecules that are not covalently cross-linked, and wherein said at least one sensory element has a fluid-conveying surface that adjoins a fluid-conveying surface of said fluidic partial system, said adjoining fluid-conveying surfaces of said at least one sensory element and said fluidic partial system being provided with a continuous film of the same hydrophilic polymer.

15. The sensory module system of claim 14, wherein said module system comprises one or more cassettes or sensory arrays, each such cassette or array comprising a plurality of sensory elements to determine substantially simultaneously a plurality of physical or chemical parameters of a single sample.

16. The sensory module system of claim 14, wherein said fluidic partial system comprises a single fluidic inlet, an open or branched fluidic transport space comprising at least one channel, and a single fluidic outlet.