Delayed release tablet with defined core geometry

  • US 8,394,407 B2
  • Filed: 03/23/2012
  • Issued: 03/12/2013
  • Est. Priority Date: 04/24/2003
  • Status: Active Grant
First Claim
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1. A press-coated tablet comprising a defined core containing a pharmaceutically active agent, and a compression coating around said core, the core being disposed within said compression coating such that the coating thickness about an axis (X-Y) is thicker and less dense than the coating about an axis (A-B) orthogonal to (X-Y), wherein said compression coating is formed of an insoluble or poorly water soluble hydrophobic material and said coating is sufficiently porous about the (X-Y) plane of the tablet to permit the ingress of aqueous media to the core at a rate to ensure release of the active agent after a period of time between 2 to 6 hours wherein said period of time is followed by rupture of the coating along the X-Y axis, wherein the compression coating lacks ingredients that swell and gel to such an extent that the coating acts as a diffusion barrier to the release of the active agent.

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