Immunogenic composition

  • US 8,398,983 B2
  • Filed: 06/23/2006
  • Issued: 03/19/2013
  • Est. Priority Date: 06/27/2005
  • Status: Active Grant
First Claim
Patent Images

1. An immunogenic composition comprising:

  • (a) a Haemophilis influenza type b (Hib) saccharide conjugate,(b) an N. meningitidis capsular saccharide conjugate derived from a strain selected from the group consisting of serogroups A, B, C, W135 and Y,(c) whole cell pertussis, and(d) hepatitis B surface antigen,wherein the saccharide dose of the Hib saccharide conjugate is less than 5 μ

    g and the saccharide dose of the N. meningitidis capsular saccharide conjugate is less than 5 μ

    g, and wherein the Geometric Mean Concentration (GMC) for whole cell pertussis or hepatitis B achieved with said immunogenic composition is higher than the GMC achieved after immunisation with said immunogenic composition containing a 5 μ

    g saccharide dose of Hib saccharide conjugate and a 5 μ

    g dose of N. meningitidis capsular saccharide conjugate.

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