Adjuvanting meningococcal factor H binding protein

  • US 8,398,988 B2
  • Filed: 02/23/2012
  • Issued: 03/19/2013
  • Est. Priority Date: 03/24/2009
  • Status: Active Grant
First Claim
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1. An immunogenic composition comprising two different meningococcal factor H binding protein (fHBP) antigens, both of which are adsorbed to aluminium hydroxyphosphate adjuvant, wherein (i) both of the meningococcal fHBP antigens have an isoelectric point between 5.0 and 7.0, and (ii) the aluminium hydroxyphosphate adjuvant has a point of zero charge between 5.0 and 7.0, wherein the two different fHBP antigens are:

  • (i) a first polypeptide comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO;

    4; and

    (ii) a second polypeptide comprising an amino acid sequence having at least 95% sequence identity to SEQ ID NO;

    6.

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