Blood flow dynamic analysis apparatus and method, and magnetic resonance imaging system

• US 8,417,317 B2
• Filed: 10/27/2009
• Issued: 04/09/2013
• Est. Priority Date: 10/31/2008
• Status: Active Grant

• Current Assignee: GE Medical Systems Global Technology Company LLC (GE Healthcare Technologies, Inc.)
• Original Assignee: GE Medical Systems Global Technology Company LLC (GE Healthcare Technologies, Inc.)
• Inventors: Kabasawa, Hiroyuki
• Primary Examiner(s): MEHTA, PARIKHA SOLANKI
• Application Number:
  US12/607,003
• Publication Number:
  US 20100113914A1
• Time in Patent Office: 1,260 Days
• Field of Search: 600/410, 600/419, 600/420, 600431-435, 382/128, 382/286, 382/291, 382/282, 382/308, 424/9.1, 424/9.3
• US Class Current: 600/420
• CPC Class Codes: A61B 5/0263 using NMR
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5608 Data processing and visualization specially adapted for MR, e.g. for feature analysis and pattern recognition on the basis of measured MR data, segmentation of measured MR data, edge contour detection on the basis of measured MR data, for enhancing measured MR data in terms of signal-to-noise ratio by means of noise filtering or apodization, for enhancing measured MR data in terms of resolution by means for deblurring, windowing, zero filling, or generation of gray-scaled images, colour-coded images or images displaying vectors instead of pixels image data processing or generation, in general G06T
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]
• CPC Class Codes: G01R 33/56366 Perfusion imaging

Abstract

A blood flow dynamic analysis apparatus acquires data from a plurality of regions lying in slices set to a subject with a contrast agent injected therein and analyzes blood flow dynamics of the subject, based on the data. The apparatus includes a contrast agent concentration profile generation device for generating profiles each indicative of a temporal change in the concentration of the contrast agent for every said region lying in the slices, a characteristic amount calculation device for calculating the concentrations of the contrast agent in the regions after a bolus of contrast agent has passed through the regions, from the profiles, a histogram generation device for generating a histogram containing the concentrations of the contrast agent in the regions after the bolus of contrast agent has passed through the regions, a region determination device for determining a region in which each vein exists, from the regions, based on the histogram, and a function calculation device for calculating a venous output function, based on a temporal change in the concentration of the contrast agent in the region in which the vein exists.

Claims

1. A blood flow dynamic analysis apparatus configured to acquire data from a plurality of regions lying in slices set to a subject with a contrast agent injected therein and to analyze blood flow dynamics of the subject based on the data, said blood flow dynamic analysis apparatus comprising:

a contrast agent concentration profile generation device configured to generate a profile indicative of a temporal change in a concentration of the contrast agent for each of the regions;

a characteristic amount calculation device configured to calculate the concentration of the contrast agent in each region as contrast agent passes through the region based on a respective profile;

a graphical representation generation device configured to generate a graphical representation containing a cluster of dots representing the concentration of the contrast agent in each region as the contrast agent passes through the region;

a region determination device configured to determine a region of the plurality of regions in which a vein exists based on the graphical representation; and

a function calculation device configured to calculate a venous output function, based on the temporal change in the concentration of the contrast agent in the region in which the vein exists.

2. The blood flow dynamic analysis apparatus according to claim 1, wherein said characteristic amount calculation device is configured to calculate a peak concentration at which the concentration of the contrast agent reaches a peak, and a peak concentration achieved time necessary for the concentration of the contrast agent to reach the peak concentration, from each of the contrast agent concentration profiles.

3. The blood flow dynamic analysis apparatus according to claim 2, wherein the cluster of dots represents at least the peak concentration and the peak concentration achieved time in each region.

4. The blood flow dynamic analysis apparatus according to claim 3, wherein said region determination device comprises:

a region extraction unit configured to extract a plurality of first regions each having a peak concentration achieved time lying in a first range based on the graphical representation;

a noise elimination unit configured to eliminate regions determined by the noise elimination unit to be noise from within the first regions; and

a region selection unit configured to select a region in which a vein exists, from the first regions with the noise eliminated therefrom, based on the concentration of the contrast agent in each of the regions as the contrast agent passes through the region.

5. The blood flow dynamic analysis apparatus according to claim 4, wherein said region selection unit is configured to select the region in which the vein exists, from the first regions with the noise eliminated therefrom, based on the peak concentration in each of the first regions and the concentration of the contrast agent in each of the first regions as the contrast agent passes through the region.

6. The blood flow dynamic analysis apparatus according to claim 4, wherein:

said region extraction unit is configured to extract a plurality of second regions each having a peak concentration achieved time lying in a second range from the regions, based on the graphical representation;

said noise elimination unit is configured to extract regions determined by the noise elimination unit to be noise from the second regions; and

said region selection unit is configured to select a region in which an artery exists, from the second regions with the regions determined to be noise eliminated therefrom, based on the peak concentration in each of the second regions.

7. The blood flow dynamic analysis apparatus according to claim 5, wherein:

said region extraction unit is configured to extract a plurality of second regions each having a peak concentration achieved time lying in a second range from the regions, based on the graphical representation;

said noise elimination unit is configured to eliminate regions determined by the noise elimination unit to be noise from the second regions; and

said region selection unit is configured to select a region in which an artery exists, from the second regions with the regions determined to be noise eliminated therefrom, based on the peak concentration in each of the second regions.

8. The blood flow dynamic analysis apparatus according to of claim 1, wherein said characteristic amount calculation device is configured to calculate the concentration of the contrast agent in each of the regions as the contrast agent passes through the region, based on the concentration of the contrast agent after a predetermined time has elapsed from a time at which the concentration of the contrast agent has reached a peak.

9. The blood flow dynamic analysis apparatus according to claim 8, wherein the predetermined time is a time ranging from 5 to 10 seconds.

10. The blood flow dynamic analysis apparatus according to claim 1, wherein the data are data acquired by a magnetic resonance imaging system.

11. A magnetic resonance imaging system comprising:

a contrast injection device configured to inject a contrast agent into a subject; and

a blood flow dynamic analysis apparatus configured to acquire data from a plurality of regions lying in slices set to the subject with a contrast agent injected therein and to analyze blood flow dynamics of the subject based on the data, wherein said blood flow dynamic analysis apparatus comprises;

a contrast agent concentration profile generation device configured to generate a profile indicative of a temporal change in a concentration of the contrast agent for each of the regions;

a characteristic amount calculation device configured to calculate the concentration of the contrast agent in each region as a contrast agent passes through the region based on a respective profile;

a graphical representation generation device configured to generate a graphical representation containing a cluster of dots representing the concentration of the contrast agent in each region as the contrast agent passes through the region;

a region determination device configured to determine a region of the plurality of regions in which a vein exists based on the graphical representation; and

a function calculation device configured to calculate a venous output function, based on the temporal change in the concentration of the contrast agent in the region in which the vein exists.

13. The magnetic resonance imaging system according to claim 11, wherein said characteristic amount calculation device is configured to calculate a peak concentration at which the concentration of the contrast agent reaches a peak, and a peak concentration achieved time necessary for the concentration of the contrast agent to reach the peak concentration, from each of the contrast agent concentration profiles.

14. The magnetic resonance imaging system according to claim 13, wherein the cluster of dots represents at least the peak concentration and the peak concentration achieved time in each region.

15. The magnetic resonance imaging system according to claim 14, wherein said region determination device comprises:

a region extraction unit configured to extract a plurality of first regions each having a peak concentration achieved time lying in a first range based on the graphical representation;

a noise elimination unit configured to eliminate regions determined by the noise elimination unit to be noise from within the first regions; and

a region selection unit configured to select the region in which a vein exists, from the first regions with the noise eliminated therefrom, based on the concentration of the contrast agent in each of the regions as the contrast agent passes through the region.

16. The magnetic resonance imaging system according to claim 15, wherein said region selection unit is configured to select the region in which the vein exists, from the first regions with the noise eliminated therefrom, based on the peak concentration and the concentration of the contrast agent in each of the first regions as the contrast agent passes through the region.

17. The magnetic resonance imaging system according to claim 15, wherein:

said region extraction unit is configured to extract a plurality of second regions each having a peak concentration achieved time lying in a second range from the regions, based on the graphical representation;

said noise elimination unit is configured to extract regions determined by the noise elimination unit to be noise from the second regions; and

said region selection unit is configured to select a region in which an artery exists, from the second regions with the regions determined to be noise eliminated therefrom, based on the peak concentration in each of the second regions.

18. The magnetic resonance imaging system according to claim 16, wherein:

said region extraction unit is configured to extract a plurality of second regions each having a peak concentration achieved time lying in a second range from the regions, based on the graphical representation;

said noise elimination unit is configured to eliminate regions determined by the noise elimination unit to be noise from the second regions; and

said region selection unit is configured to select a region in which an artery exists, from the second regions with the regions determined to be noise eliminated therefrom, based on the peak concentration of the contrast agent.

19. The magnetic resonance imaging system according to of claim 11, wherein said characteristic amount calculation device is configured to calculate the concentration of the contrast agent in each of the regions as the contrast agent passes through the region, based on the concentration of the contrast agent after a predetermined time has elapsed from a time at which the concentration of the contrast agent has reached a peak.

20. The magnetic resonance imaging system according to claim 19, wherein the predetermined time is a time ranging from 5 to 10 seconds.

12. A method of a blood flow dynamic analysis for acquiring data from a plurality of regions lying in slices set to a subject with a contrast agent injected therein and analyzing blood flow dynamics of the subject, based on the data, said method comprising:

generating, by a profile generation device, profiles each indicative of a temporal change in the concentration of contrast agent for every region lying in the slices;

calculating a concentration of the contrast agent in each of the regions as a contrast agent passes through the regions, from the profiles;

generating, by a graphical representation generation device, a graphical representation containing a cluster of dots that represent a relationship of three characteristic amounts of the concentration of the contrast agent in the regions as the contrast agent passes through the regions;

determining, by a region extraction unit, a region in which a vein exists, from the regions, based on the graphical representation; and

calculating, by the region extraction unit, a venous output function, based on a temporal change in the concentration of the contrast agent in the region in which the vein exists.