Composition and methods of treatment using deionized and ozonated solution

• US 8,420,699 B1
• Filed: 10/31/2011
• Issued: 04/16/2013
• Est. Priority Date: 06/19/2002
• Status: Expired due to Fees

• Current Assignee: Irvine L. Dubow
• Original Assignee: Irvine L. Dubow
• Inventors: Dubow, Irvine L.
• Primary Examiner(s): FAY, ZOHREH A
• Application Number:
  US13/286,213
• Time in Patent Office: 533 Days
• Field of Search: 514/547, 514/772.3, 514/912
• US Class Current: 514/547
• CPC Class Codes: A61K 31/225 Polycarboxylic acids
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/186 Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/0048 Eye, e.g. artificial tears

Abstract

Therapeutically effective compositions and methods to inhibit dry eye as well as other conditions are provided. A therapeutically effective composition consists of at least one surfactant; a preservative with reduced immunogenicity relative to thimerosol; a complexing agent; and deionized, demineralized, ozonated water.

Claims

1. An antimicrobial composition consisting essentially of:

deionized, demineralized, ozonated water;

at least one non-ionic surfactant; and

in combination, a preservative with reduced immunogenicity relative to thimerosol and a complexing agent, the combination in an effective amount to induce a killing or inhibitory effect upon microorganisms or disease-inducing matter contacted by the composition.

2. The composition of claim 1 further comprising a fatty acid humectant.

3. The composition of claim 2 wherein the fatty acid humectant is glycerin.

4. The composition of claim 3 which comprises about 0.5% to about 1.0% by weight glycerin.

5. The composition of claim 1 further comprising a second surfactant.

6. The composition of claim 5 wherein the second surfactant is Tween 80.

7. The composition of claim 6 which comprises about 0.05% to about 1.0% by weight Tween 80.

8. The composition of claim 1 wherein the preservative is parabens.

9. The composition of claim 8 which comprises about 0.1% to about 2% by weight paraben.

10. The composition of claim 1 wherein the complexing agent is EDTA.

11. The composition of claim 10 which comprises about 0.01% to about 1.0% by weight EDTA.

12. The composition of claim 1 wherein the at least one surfactant is tyloxapol.

13. The composition of claim 12 which comprises about 0.01% to about 1.0% by weight tyloxapol.

14. The composition of claim 1 which is primarily non-ionic.

15. The composition of claim 1 which comprises tyloxapol, parabens and EDTA.

16. The composition of claim 1 which comprises tyloxapol, parabens, EDTA, glycerin and Tween 80.

17. The composition of claim 1 which is non-ionic.

18. A topical, therapeutically effective pharmaceutical composition consisting essentially of:

deionized, demineralized, ozonated water;

at least one non-ionic surfactant; and

an antimicrobial agent having a preservative with reduced immunogenicity relative to thimerosol and a complexing agent;

the composition which comprises tyloxapol, parabens, EDTA, glycerin and Tween 80.