Therapeutic calcium phosphate particles and methods of manufacture and use
DCFirst Claim
1. Calcium phosphate particles having an average diameter between about 300 nm and about 4000 nm, and having a substantially spherical shape and a substantially smooth surface.
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Abstract
Novel calcium phosphate core particles, methods of making them, and methods of using them as vaccine adjuvants, as cores, as carriers of biologically active material, and as controlled release matrices for biologically active material are disclosed. The core particles may have a surface modifying agent and/or biologically active material, such as antigenic material or natural immunoenhancing factor, polynucleotide material, or therapeutic proteins or peptides, partially coating the particle or impregnated therein. The core particles have a diameter between about 300 nm and about 4000 nm, more particularly between about 300 nm and about 2000 nm, and even more particularly between about 300 nm and about 1000 nm, are substantially spherical in shape, and have a substantially smooth surface.
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3 Claims
- 1. Calcium phosphate particles having an average diameter between about 300 nm and about 4000 nm, and having a substantially spherical shape and a substantially smooth surface.
Specification