Dendrimer conjugates
First Claim
1. A dendrimer conjugate comprising a linker,wherein said linker is selected from the group consisting of an elimination linker, a cyclization linker, a glucoronidase sensitive linker, a branched self-elimination linker, a heteroaromatic nitrogen containing compound linker, and a hypoxia induced linker,wherein said linker is conjugated to a G5 PAMAM dendrimer and at least one ligand selected from the group consisting of a therapeutic agent, an imaging agent, and a targeting agent.
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Abstract
The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
112 Citations
10 Claims
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1. A dendrimer conjugate comprising a linker,
wherein said linker is selected from the group consisting of an elimination linker, a cyclization linker, a glucoronidase sensitive linker, a branched self-elimination linker, a heteroaromatic nitrogen containing compound linker, and a hypoxia induced linker, wherein said linker is conjugated to a G5 PAMAM dendrimer and at least one ligand selected from the group consisting of a therapeutic agent, an imaging agent, and a targeting agent.
Specification