Use of a polyphenol for the treatment of a cancerous or precancerous lesion of the skin

• US 8,455,022 B2
• Filed: 03/18/2011
• Issued: 06/04/2013
• Est. Priority Date: 10/09/2003
• Status: Active Grant

• Current Assignee: Fougera Pharmaceuticals Incorporated (Novartis Ag)
• Original Assignee: Medigene AG
• Inventors: Stockfleth, Eggert
• Primary Examiner(s): Mi, Qiuwen
• Application Number:
  US13/051,593
• Publication Number:
  US 20110166219A1
• Time in Patent Office: 809 Days
• Field of Search: None
• US Class Current: 424/729
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61K 31/7048 having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin , digitoxin or digoxin
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 35/00 Antineoplastic agents

Abstract

The present invention refers to a method for treating cancerous or precancerous lesions of the skin by administering a pharmaceutically effective amount of a polyphenol to a patient as well as to the production of a medicament thereto.

Claims

1. A method for treating a lesion of the skin in a patient, wherein said skin lesion is molluscum contagiosum, said method comprising topically administering a pharmaceutically effective amount of a polyphenol composition comprising (i) a mixture of polyphenols and (ii) a carrier, wherein the composition comprises from about 5% (w/w) to about 20% (w/w) of the mixture of polyphenols, wherein the mixture of polyphenols contains epicatechol, epicatechol gallate, epigallocatechol, epigallocatechol gallate, and qallocatechol gallate.

2. The method according to claim 1, wherein the patient is a human.

3. The method according to claim 1, wherein the mixture of polyphenols is isolated from tea or a tea extract.

4. The method according to claim 3, wherein the tea is a green tea.

5. The method according to claim 3, wherein the tea extract is a green tea extract.

6. The method according to claim 1, wherein the mixture of polyphenols contains (−

)-epicatechol, (−

)-epicatechol gallate, (−

)-epigallocatechol, (−

)-epigallocatechol gallate, (+) gallocatechol and/or (−

)-gallocatechol gallate.

7. The method according to claim 6, wherein the mixture of polyphenols contains about 2-20% (w/w) epicatechol, about 2-20% (w/w) epicatechol gallate, about 1-25% (w/w) epigallocatechol, about 40-75% (w/w) epigallocatechol gallate, and about 0.5-20% (w/w) gallocatechol gallate.

8. The method according to claim 6, wherein the mixture of polyphenols contains about 10.8% (w/w) of epicatechol, about 6.5% (w/w) of epicatechol gallate, about 9.2% (w/w) of epigallocatechol, about 54.8% (w/w) of epigallocatechol gallate and/or about 4.0% (w/w) of gallocatechol gallate.

9. The method according to claim 6, wherein the mixture of polyphenols contains about 10.8% (w/w) of (−

)-epicatechol, about 6.5% (w/w) of (−

)-epicatechol gallate, about 9.2% (w/w) of (−

)-epigallocatechol, about 54.8% (w/w) of (−

)-epigallocatechol gallate and about 4.0% (w/w) of (−

)-gallocatechol gallate.

10. The method according to claim 1, wherein the mixture of polyphenols is combined with an additive.

11. The method according to claim 10, wherein the additive is selected from the group consisting of petroleum jelly, wax, oleyl alcohol, propylene glycol monostearate, propylene glycol monopalmitostearate and/or isopropyl myristate.

12. The method according to claim 1, wherein the mixture of polyphenols is contained in a carrier selected from the group consisting of an emulsion, a gel, a cream and/or an ointment.

13. The method according to claim 1, wherein the composition comprises about 15% (w/w) mixture of polyphenols.

14. A method for treating a lesion of the skin in a patient, wherein said skin lesion is molluscum contagiosum, said method comprising topically administering a pharmaceutically effective amount of a polyphenol composition comprising (i) a mixture of polyphenols and (ii) a carrier, wherein the composition comprises about 15% (w/w) mixture of polyphenols, wherein the mixture of polyphenols contains about 10.8% (w/w) of (−

)-epicatechol, about 6.5% (w/w) of (−

)-epicatechol gallate, about 9.2% (w/w) of (−

)-epigallocatechol, about 54.8% (w/w) of (−

)-epigallocatechol gallate, and about 4.0% (w/w) of (−

)-gallocatechol gallate.