Spun nanofiber, medical devices, and methods
First Claim
Patent Images
1. A biostable nanofiber formed from a compound of the formula (Formula I):
-
[(R2O)3—
Si—
R3]z—
Y—
[(R1)m—
Ox]q—
Y′
—
[R3—
Si—
(OR2)3]z where x and z are each independently 0 or 1;
m is 1 to 18;
q is 1 to 200;
R1, R2 and R3 are each independently an organic group;
and Y and Y′
are selected together from the group consisting of;
—
O—
(C═
O)—
for Y and —
(C═
O)—
for Y′
where z=1;
—
(NR4)—
(C═
O)—
(NH)—
for Y and Y′
, where z=1, and R4 is an organic group; and
—
N—
[CH2—
(CHOH)—
CH2—
O—
R3—
Si—
(OR2)3]2 for Y and Y′
, where z=0;
where the biostable nanofiber is produced by a spinning process.
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Abstract
The present disclosure relates to compounds from which nanofibers can be produced, the resulting nanofibers produced from the compounds, and nanofiber reinforced polymers prepared using the nanofibers and a polymer. The compounds used in forming the nanofibers include chemical linkage moieties that are capable of forming non-covalent bonds with portions of the polymer so as to form the nanofiber reinforced polymers. The nanofiber reinforced polymers are useful as biomaterials in medical devices.
217 Citations
20 Claims
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1. A biostable nanofiber formed from a compound of the formula (Formula I):
-
[(R2O)3—
Si—
R3]z—
Y—
[(R1)m—
Ox]q—
Y′
—
[R3—
Si—
(OR2)3]zwhere x and z are each independently 0 or 1;
m is 1 to 18;
q is 1 to 200;
R1, R2 and R3 are each independently an organic group;and Y and Y′
are selected together from the group consisting of;—
O—
(C═
O)—
for Y and —
(C═
O)—
for Y′
where z=1;—
(NR4)—
(C═
O)—
(NH)—
for Y and Y′
, where z=1, and R4 is an organic group; and—
N—
[CH2—
(CHOH)—
CH2—
O—
R3—
Si—
(OR2)3]2 for Y and Y′
, where z=0;where the biostable nanofiber is produced by a spinning process. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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-
11. A biostable nanofiber reinforced polymer, comprising:
-
a polymer; and nanofibers from a compound of the formula (Formula I);
[(R2O)3—
Si—
R3]z—
Y—
[(R1)m—
Ox]q—
Y′
—
[R3—
Si—
(OR2)3]zwhere x and z are each independently 0 or 1;
m is 1 to 18;
q is 1 to 200;
R1, R2 and R3 are each independently an organic group;and Y and Y′
are selected together from the group consisting of;—
O—
(C═
O)—
for Y and —
(C═
O)—
for Y′
where z=1;—
(NR4)—
(C═
O)—
(NH)—
for Y and Y′
, where z=1, and R4 is an organic group; and—
N—
[CH2—
(CHOH)—
CH2—
O—
R3—
Si—
(OR2)3]2 for Y and Y′
, where z=0, where the biostable nanofibers include chemical moieties capable of forming a non-covalent bond with portions of the polymer. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification