Irreversible electroporation using nanoparticles
First Claim
Patent Images
1. A method of treating a subject suffering from a neoplasia, said method comprising:
- identifying a treatment area in the subject, wherein the treatment area comprises neoplasia;
administering a first therapeutically effective amount of nanoparticles to the subject in need thereof such that at least some of the nanoparticles come in close proximity to neoplastic cells of the neoplasia;
positioning at least one electrode into or adjacent the neoplastic cells;
applying an electric field to the treatment area by delivering electrical pulses from the at least one electrode to cause non-thermal irreversible electroporation of the neoplastic cells; and
orienting the nanoparticles in relationship to the electric field such that the electric field is enhanced, the treatment area is enlarged, a more precisely defined treatment margin is achieved, or tumor margins are more selectively treated.
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides methods, devices, and systems for in vivo treatment of cell proliferative disorders. The invention can be used to treat solid tumors, such as brain tumors. The methods rely on non-thermal irreversible electroporation (IRE) to cause cell death in treated tumors. In embodiments, the methods comprise the use of high aspect ratio nanoparticles with or without modified surface chemistry.
292 Citations
28 Claims
-
1. A method of treating a subject suffering from a neoplasia, said method comprising:
-
identifying a treatment area in the subject, wherein the treatment area comprises neoplasia; administering a first therapeutically effective amount of nanoparticles to the subject in need thereof such that at least some of the nanoparticles come in close proximity to neoplastic cells of the neoplasia; positioning at least one electrode into or adjacent the neoplastic cells; applying an electric field to the treatment area by delivering electrical pulses from the at least one electrode to cause non-thermal irreversible electroporation of the neoplastic cells; and orienting the nanoparticles in relationship to the electric field such that the electric field is enhanced, the treatment area is enlarged, a more precisely defined treatment margin is achieved, or tumor margins are more selectively treated. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
-
26. A method of treating a subject suffering from a neoplasia, said method comprising:
-
identifying a treatment area in the subject, wherein the treatment area comprises neoplasia; administering a therapeutically effective amount of nanoparticles to the subject in need thereof such that at least some of the nanoparticles come in close proximity to neoplastic cells of the neoplasia; positioning at least one electrode into or adjacent the neoplastic cells; applying an electric field to the treatment area by delivering electrical pulses from the at least one electrode to cause electroporation of the neoplastic cells; and orienting the nanoparticles such that the electric field is enhanced, the treatment area is enlarged, a more precisely defined treatment margin is achieved, or the tumor margins are more selectively treated. - View Dependent Claims (27, 28)
-
Specification