Orally effective methylphenidate extended release powder and aqueous suspension product

  • US 8,465,765 B2
  • Filed: 09/12/2012
  • Issued: 06/18/2013
  • Est. Priority Date: 02/15/2011
  • Status: Active Grant
First Claim
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1. A methylphenidate aqueous extended release oral suspension comprising (1) an immediate release methylphenidate component, (2) a sustained release methylphenidate component comprising a water-insoluble, water-permeable, pH-independent, barrier coated methylphenidate-ion exchange resin complex, and (3) water,wherein said suspension has a pH of about 3.5 to about 5 and said suspension provides a single mean average plasma concentration peak for methylphenidate and a therapeutically effective plasma profile for methylphenidate for about 12 hours.

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