Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

• US 8,470,180 B2
• Filed: 08/03/2012
• Issued: 06/25/2013
• Est. Priority Date: 05/22/2006
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Leonard, Edward F., West, Alan C., Aucoin, Christian Paul, Nanne, Edgar E.
• Primary Examiner(s): Kim, John
• Application Number:
  US13/566,592
• Publication Number:
  US 20120292253A1
• Time in Patent Office: 326 Days
• Field of Search: 210/97, 210/137, 210/200, 210/203, 210/209, 210/511, 210/643, 210/644, 210/645, 210/646, 210/647, 210/649, 210/650, 210/651, 210/634, 210/767, 210/806, 604/5.01, 604/5.04, 604/6.01, 604/6.02, 604/6.09, 604/6.11
• US Class Current: 210/643
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1696 with dialysate regeneration
• CPC Class Codes: A61M 1/32 Oxygenators without membranes
• CPC Class Codes: A61M 2205/7563 with means preventing clogging of filters
• CPC Class Codes: A61M 2206/11 Laminar flow
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04
• CPC Class Codes: B01D 11/0492 Applications, solvents used
• CPC Class Codes: B01D 11/0496 by extraction in microfluidic devices
• CPC Class Codes: G01N 2030/0045 normal, i.e. diffusion or thermal FFF

Abstract

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid'"'"'s properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Claims

1. A method for purifying blood, comprising:

separating macromolecular blood components from whole blood from a patient'"'"'s blood stream using a microporous filter, the separating including flowing the whole blood through a microfluidic channel in which the microporous filter is configured to form a portion of a wall of the microfluidic channel such that crossflow exists across the wall creating a shear rate sufficient to sweep blood cells from the surface of the microporous filter;

wherein the microporous filter has a regular array of pores whose diameters are less than 800 nm, each pore defining non-serpentine, non-branching channels;

wherein the microfluidic channel has a depth across the direction of flow which is between 75 and 300 microns, and a width, perpendicular to the depth, that is at least ten times the depth;

ultrafiltering the blood components and returning ultrafiltered blood components to the patient minus some water and micromolecular components passed by an ultrafilter used for said ultrafiltering.

2. The method of claim 1, wherein the returning includes flowing the ultrafiltered blood components into the microfluidic channel.

3. The method of claim 2, wherein the blood components comprise blood serum including albumin.

4. The method of claim 1, wherein the blood components comprise blood serum including albumin.

5. The method of claim 1, wherein the separating includes using multiple microporous filters separated across said microfluidic channel.

6. The method of claim 1, wherein the microfluidic channel has a cross-section cutting across a direction of flow whose aspect ratio is greater than ten.

7. The method of claim 1, wherein the depth is about 120 microns.

8. The method of claim 1, wherein ultrafiltering includes passing urea through a membrane.