Stable protein formulations

CAFC
  • US 8,476,239 B2
  • Filed: 12/19/2006
  • Issued: 07/02/2013
  • Est. Priority Date: 12/20/2005
  • Status: Active Grant
First Claim
Patent Images

1. A stable formulation suitable for subcutaneous administration comprising at least 100mg/ml CTLA4Ig molecule, a sugar selected from the group consisting of sucrose, lactose, maltose, mannitol and trehalose and mixtures thereof and a pharmaceutically acceptable aqueous carrier, wherein the formulation has a pH range of from 6 to 8 and a viscosity of from 9 to 20 cps, and the weight ratio of sugar:

  • protein is 1.1;

    1 or higher.

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