Nanoparticle precursor structures, nanoparticle structures, and composite materials

• US 8,481,643 B2
• Filed: 09/21/2010
• Issued: 07/09/2013
• Est. Priority Date: 12/23/2005
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Ippoliti, J. Thomas, Schewe, Scott R., Atanasoska, Liliana L., Warner, Robert W.
• Primary Examiner(s): Peng, Kuo-Liang
• Application Number:
  US12/887,354
• Publication Number:
  US 20110009541A1
• Time in Patent Office: 1,022 Days
• Field of Search: 524/858
• US Class Current: 524/858
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites
• CPC Class Codes: C08J 5/005 Reinforced macromolecular compounds with nanosized materials, e.g. nanoparticles, nanofibres, nanotubes, nanowires, nanorods or nanolayered materials
• CPC Class Codes: C08K 9/04 Ingredients treated with organic substances treated with macromolecular compounds C08K9/08
• CPC Class Codes: Y10S 977/773 Nanoparticle, i.e. structure having three dimensions of 100 nm or less
• CPC Class Codes: Y10S 977/778 within specified host or matrix material, e.g. nanocomposite films
• CPC Class Codes: Y10S 977/783 Organic host/matrix, e.g. lipid
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]
• CPC Class Codes: Y10T 428/2991 Coated
• CPC Class Codes: Y10T 428/2993 Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
• CPC Class Codes: Y10T 428/2998 including synthetic resin or polymer
• CPC Class Codes: Y10T 428/31663 As siloxane, silicone or silane

Abstract

Nanoparticle precursor structures, nanoparticle structures, and composite materials that include the nanoparticle structures in a polymer to form a composite material. The nanoparticle structures have chemical linkage moieties capable of forming non-covalent bonds with portions of a polymer for the composite material. Such composite materials are useful as biomaterials in medical devices.

Claims

1. A method of forming a composite material, comprising:

providing at least one alcohol of the formula ROH where R is an organic group;

dissolving a polymer having groups capable of forming non-covalent bonds in the at least one alcohol;

providing at least one silicon containing compound of the formula (R₁O)_wSi(R₂—

N═

C═

O)_z where;

R₁, R₂ are each independently an organic group, and w and z are each independently 1 to 3;

reacting the at least one silicon containing compound with the at least one alcohol to form the nanoparticle precursor structure of the formula (R₁O)_wSi(R₂—

(NH)—

(C═

O)—

O—

R)_z;

providing at least one silicon alkoxide of the formula Si(OR₃)₄, where R₃ is an organic group; and

reacting at least one silicon alkoxide of the formula Si(OR₃)₄ with the nanoparticle precursor structure of the formula (R₁O)_wSi(R₂-A-R)_z to form the nanoparticle structure having a core of crosslink silicon oxides with the group (R₂-A-R)_z covalently bonded to the core, where A is a portion that can form a non-covalent bond with the non-covalent bonding groups of the polymer to disperse the nanoparticle structure in the polymer.

2. The method of claim 1, where each R, R₁, and R₃ is independently a (C1-C8) alkyl group, and R₂ is a (C1-C18) alkylene group.

3. The method of claim 1, where A is a urethane group.

4. The method of claim 1, where the core of crosslink silicon oxides is formed using a sol-gel process.

5. The method of claim 1, including forming the composite material with the polymer present.